Objective: Stimulant medications, such as methylphenidate and amphetamines, are commonly prescribed to treat attention deficit hyperactivity disorder. Stimulant use increased fourfold from 1987 ( 0.6%) to 1996 ( 2.4%) among subjects 18-year- old and younger in the U. S. The aim of this study was to determine whether pediatric use of stimulants continued to rise during the period 1997 - 2002. Method: The Medical Expenditure Panel Survey ( MEPS) database for the years 1997 - 2001 was analyzed. The MEPS is a yearly survey of a nationally representative sample of civilian, noninstitutionalized U. S. households, conducted by the U. S. Agency for Health Care Research and Quality. Previously reported estimates from the 1996 MEPS and the 1987 National Medical Expenditure Survey, the predecessor to MEPS, were also replicated to compare recent trends to changes between 1987 and 1996. Results: The prevalence use of stimulants among subjects under 19 years of age was 2.7% ( 95% C.I. 2.3 - 3.1) in 1997 and 2.9% ( 95% C.I. 2.5 - 3.3) in 2002, with no statistically significant change during these 6 years. Likewise, when pooling data across years and comparing the rate in 1997 - 1998 ( 2.8%) with the rate in 2001 - 2002 ( 3.0%), no statistically significant changes emerged. Use was highest among 6 - 12 year olds ( 4.8% in 2002), as compared with 3.2% among 13 - 19 year olds and 0.3% among children under 6. An estimated 2.2 million ( 95% C.I. 1.9 - 2.6) children received stimulant medication in 2002 as compared to 2.0 million ( 95% C.I. 1.7 - 2.3) in 1997. Conclusions: The steep increase in the utilization of stimulants among children 18 years and younger that occurred over the 1987 - 1996 period attenuated in the following years through 2002, and has remained stable among very young children.
机构:
US FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USA
Ctr Dis Control & Prevent, Epidem Intelligence Serv, Div Workforce Dev, Atlanta, GA USAUS FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USA
Innes, Gabriel K.
Ogden, Cynthia L.
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Ctr Dis Control & Prevent, Hyattsville, MD USAUS FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USA
Ogden, Cynthia L.
Crentsil, Victor
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US FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USAUS FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USA
Crentsil, Victor
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Concato, John
Fakhouri, Tala H.
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US FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USAUS FDA, Off Med Policy, Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20903 USA
机构:
Boston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Boston Childrens Hosp, Dept Lab Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Vaz, Louise Elaine
Kleinman, Kenneth P.
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Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Aurora, CO USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Kleinman, Kenneth P.
Raebel, Marsha A.
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Kaiser Permanente Colorado Inst Hlth Res, Denver, CO USA
Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Aurora, CO USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Raebel, Marsha A.
Nordin, James D.
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Hlth Partners Inst Educ & Res, Minneapolis, MN USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Nordin, James D.
Lakoma, Matthew D.
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Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Lakoma, Matthew D.
Dutta-Linn, M. Maya
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Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA
Dutta-Linn, M. Maya
Finkelstein, Jonathan A.
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Harvard Univ, Sch Med, Dept Populat Med, Boston, MA USABoston Childrens Hosp, Div Infect Dis, Boston, MA 02115 USA