TWO MIXED-LIGAND Cu(II)-BASED COORDINATION POLYMERS: CRYSTAL STRUCTURES AND TREATMENT ACTIVITY ON CHILD ACUTE PANCREATITIS WITH PERITONITIS BY INHIBITING THE BACTERIAL SURVIVAL

Two mixed-ligand coordination polymers with the chemical formulae {[Cu(3()Hdpc)(2)(tib)(2)(H2O)(2)]center dot 2H(2)O)}(n)(1, H(3)dpc = 2,6-di(4-carboxylphenyl)pyridine-4-carboxylic acid, tib = 1,3,5-tris(1-imidazolyl)benzene)) and [Cu(trans-chda)(2)(bimb)(2 center dot)2H(2)O](n)(2, H(2)chda = 1,4-cyclohexane(dicarboxylic)acid, bimb = 1,4-bis((1H-1,2,4-triazol-1-yl)methyl)benzene) are successfully prepared by the reaction of Cu(NO3)(2 center dot)3H(2)O with different O-donor carboxylic acid and N-donor co-ligands under the solvothermal conditions. Furthermore, the treatment effect of the two compounds on the acute pancreatitis is evaluated in the biological experiment. Firstly, RT-PCR is performed to measure the relative expression level of the key genes ofE. coli. Moreover, the inflammatory levels of the patients are evaluated by the ELISA detection of inflammatory cytokines, IL-1 beta, and TNF-alpha.