Sym004, a novel anti-EGFR antibody mixture augments radiation response in human lung and head and neck cancer models

被引:0
|
作者
Huang, Shyhmin [1 ]
Armstrong, Eric A. [1 ]
Kragh, Michael [2 ]
Pedersen, Mikkel W. [2 ]
Harari, Paul M. [1 ]
机构
[1] Univ Wisconsin, Madison, WI USA
[2] Symphogen AS, Lyngby, Denmark
关键词
D O I
10.1158/1538-7445.AM2012-2720
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2720
引用
收藏
页数:2
相关论文
共 50 条
  • [21] Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
    Pedersen, Mikkel Wandahl
    Jacobsen, Helle Jane
    Koefoed, Klaus
    Hey, Adam
    Pyke, Charles
    Haurum, John Sorensen
    Kragh, Michael
    CANCER RESEARCH, 2010, 70 (02) : 588 - 597
  • [22] Panitumumab, a fully human Anti-EGFR monoclonal antibody, augments radiation response in xenograft models of upper aerodigestive tract cancers
    Kruser, T. J.
    Armstrong, E.
    Huang, S.
    Radinsky, R.
    Stames, C.
    Freeman, D.
    Harari, P. M.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 69 (03): : S615 - S616
  • [23] Pan-HER Inhibitor Augments Radiation Response in Human Lung and Head and Neck Cancer Models
    Francis, David M.
    Huang, Shyhmin
    Armstrong, Eric A.
    Werner, Lauryn R.
    Hullett, Craig
    Li, Chunrong
    Morris, Zachary S.
    Swick, Adam D.
    Kragh, Michael
    Lantto, Johan
    Kimple, Randall J.
    Harari, Paul M.
    CLINICAL CANCER RESEARCH, 2016, 22 (03) : 633 - 643
  • [24] Phase I dose-escalation trial of Sym004, a mixture of two anti-EGFR antibodies, in Japanese patients with advanced solid tumors.
    Kato, Ken
    Kojima, Takashi
    Yamazaki, Kentaro
    Muro, Kei
    Hara, Hiroki
    Chin, Keisho
    Goddemeier, Thomas
    Watanabe, Morihiro
    Doi, Toshihiko
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [25] Impact of HPV status on the response of head and neck cancers to the anti-EGFR antibody cetuximab
    Pogorzelski, M.
    Ting, S.
    Gauler, T. C.
    Vossebein, I
    Breitenbuecher, F.
    Lang, S.
    Hoffmann, T. K.
    Bergmann, C.
    Schmid, K. W.
    Schuler, M.
    Kasper, S.
    ONKOLOGIE, 2012, 35 : 193 - 193
  • [26] Perspectives of combined radioimmunotherapy and anti-EGFR antibody therapy for the treatment of residual head and neck cancer
    van Gog, FB
    Brakenhoff, RH
    Stigter-van Walsum, M
    Snow, GB
    van Dongen, GAMS
    INTERNATIONAL JOURNAL OF CANCER, 1998, 77 (01) : 13 - 18
  • [27] Phase I trial and tumour localisation of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer
    Modjtahedi, H
    Hickish, T
    Nicolson, M
    Moore, J
    Styles, J
    Eccles, S
    Jackson, E
    Salter, J
    Sloane, J
    Spencer, L
    Priest, K
    Smith, I
    Dean, C
    Gore, M
    BRITISH JOURNAL OF CANCER, 1996, 73 (02) : 228 - 235
  • [28] Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: Implications for anti-EGFR treatment response
    Boeckx C.
    Weyn C.
    Vanden Bempt I.
    Deschoolmeester V.
    Wouters A.
    Specenier P.
    Van Laer C.
    Van Den Weyngaert D.
    Kockx M.
    Vermorken J.B.
    Peeters M.
    Pauwels P.
    Lardon F.
    Baay M.
    BMC Research Notes, 7 (1)
  • [29] Efficacy and safety of Sym004 in refractory metastatic colorectal cancer with acquired resistance to anti-EGFR therapy: Results of a randomized phase II study (RP2S)
    Tabernero, J.
    Ciardiello, F.
    Montagut, C.
    Ding, C.
    Kopetz, S.
    Poulsen, T. Tuxen
    Bardelli, A.
    Wyrwicz, L.
    Cubillo, A.
    Santos, C.
    Fumi, G.
    Zagonel, V.
    Bennouna, J.
    Siena, S.
    Falcone, A.
    Benavent, M.
    Argiles, G.
    Kragh, M.
    Horak, I. D.
    Dvorkin, M.
    ANNALS OF ONCOLOGY, 2017, 28
  • [30] In vivo molecular imaging with cetuximab, an anti-EGFR antibody, for prediction of response in xenograft models of human colorectal cancer
    Goetz, M.
    Hoetker, M. S.
    Diken, M.
    Galle, P. R.
    Kiesslich, R.
    ENDOSCOPY, 2013, 45 (06) : 469 - 477