The neurobiological effects of repetitive head impacts in collision sports

被引：21
|
作者：
Hunter, Liane E. [1 ,2 ]
Branch, Craig A. [1 ,2 ,3 ,4 ]
Lipton, Michael L. [1 ,2 ,3 ,5 ,6 ,7 ]
机构：
[1] Albert Einstein Coll Med, Gruss Magnet Resonance Imaging Ctr, Bronx, NY 10467 USA
[2] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Dept Radiol, Bronx, NY 10467 USA
[4] Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10467 USA
[5] Albert Einstein Coll Med, Dept Psychiat, Bronx, NY USA
[6] Albert Einstein Coll Med, Dept Behav Sci, Bronx, NY 10467 USA
[7] Albert Einstein Coll Med, Dominick P Purpura Dept Neurosci, Bronx, NY 10467 USA
来源：
NEUROBIOLOGY OF DISEASE | 2019年 / 123卷
基金：
美国国家卫生研究院;
关键词：
Repetitive head injuries; Mild traumatic brain injury; Collision sports; METABOLIC BRAIN VULNERABILITY; NEURON-SPECIFIC ENOLASE; TEMPORAL WINDOW; ANIMAL-MODELS; SERUM-LEVELS; BIOCHEMICAL MARKERS; BARRIER FUNCTION; AEROBIC FITNESS; SOCCER PLAYERS; DAMAGE S-100B;
D O I：
10.1016/j.nbd.2018.06.016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.
引用
收藏
页码：122 / 126
页数：5
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