Bacteriophage therapy as a treatment option for transplant infections

被引:13
|
作者
Aslam, Saima [1 ]
机构
[1] Univ Calif San Diego, Ctr Innovat Phage Applicat & Therapeut, Div Infect Dis & Global Publ Hlth, San Diego, CA 92103 USA
关键词
bacteriophage; multidrug-resistant; phage; transplant; RESISTANCE; CANDIDATES;
D O I
10.1097/QCO.0000000000000658
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Purpose of review Since initial description of the successful use of intravenous bacteriophage therapy in the United States in 2017, there is widespread interest in using bacteriophage therapy for multidrug-resistant (MDR) infections. Recent findings Recent published cases of bacteriophage therapy in transplant candidates and recipients are reviewed highlighting its safety and potential efficacy when used as an adjunct to systemic antibiotics for a variety of clinical indications. An overview of access to bacteriophage therapy in the United States is also provided. The reviewed cases form the basis for ongoing compassionate use of bacteriophage therapy in transplant candidates and recipients with life-threatening MDR infections until data from clinical trials are available to guide therapy.
引用
收藏
页码:298 / 303
页数:6
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