Electrochemically Enabled Dehydrogenative Phosphorothiolation of 2H-Indazoles under Electrolyte-Free Conditions

被引:27
|
作者
Ghosh, Payel [1 ]
Hajra, Alakananda [1 ]
机构
[1] Visva Bharati, Dept Chem, Santini Ketan 731235, W Bengal, India
关键词
Electrooxidation; Phosphorothiolation; cross dehydrogenative coupling; Electrolyte-free; 2H-indazole; BORONIC ACIDS; FUNCTIONALIZATION; AMINATION; ACCESS;
D O I
10.1002/adsc.202200932
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
We have developed an electrochemical method for phosphorothiolation of 2H-indazoles using S-hydrogen phosphorothioates via cross dehydrogenative coupling reaction under metal-free and electrolyte-free conditions. This protocol is compatible with electron donating groups like -Me, -OMe, halogen and elctron withdrawing groups such as -COOEt, affording respective indazolyl phosphorothioates in 62%-91% yields. Comprehensive mechanistic studies indicate that the reaction proceeds through a radical pathway.
引用
收藏
页码:4157 / 4165
页数:9
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