X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation

被引:9
|
作者
Su Cun-Jin [1 ,2 ]
Xu Jian-Hao [3 ]
Liu Xu [2 ]
Zhao Feng-Lun [1 ]
Pan Jie [1 ]
Shi Ai-Ming [1 ]
Hu Duan-Min [4 ]
Yu Yun-Li [5 ]
Liu Tong [2 ,6 ]
Zhang Yu-Song [3 ]
机构
[1] Soochow Univ, Affiliated Hosp 2, Dept Pharm, Suzhou, Peoples R China
[2] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China
[3] Soochow Univ, Affiliated Hosp 2, Dept Oncol, Suzhou, Peoples R China
[4] Soochow Univ, Affiliated Hosp 2, Dept Gastroenterol, Suzhou, Peoples R China
[5] Soochow Univ, Affiliated Hosp 2, Dept Clin Pharmacol, Suzhou, Peoples R China
[6] Yanan Univ, Coll Life Sci, Yanan, Peoples R China
来源
MOLECULAR PAIN | 2019年 / 15卷
基金
美国国家科学基金会;
关键词
X-ray; radiation; pain; transient receptor potential vanilloid 1; transient receptor potential ankyrin 1; dorsal root ganglion; INDUCED PERIPHERAL NEUROPATHY; ALPHA-LIPOIC ACID; IONIZING-RADIATION; PAIN; RADIOTHERAPY; CANCER; STRESS; SKIN; IRRADIATION; MANAGEMENT;
D O I
10.1177/1744806919849201
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this study, mice were treated with 20 Gy X-ray to establish ionizing radiation-induced pain model. X-ray evoked a prolonged mechanical, heat, and cold allodynia in mice. Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 were significantly upregulated in lumbar dorsal root ganglion. The mechanical and heat allodynia could be transiently reverted by intrathecal injection of transient receptor potential vanilloid 1 antagonist capsazepine and transient receptor potential ankyrin 1 antagonist HC-030031. Additionally, the phosphorylated extracellular regulated protein kinases (ERK) and Jun NH2-terminal Kinase (JNK) in pain neural pathway were induced by X-ray treatment. Our findings indicated that activation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 is essential for the development of X-ray-induced allodynia. Furthermore, our findings suggest that targeting on transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 may be promising prevention strategies for X-ray-induced allodynia in clinical practice.
引用
收藏
页数:13
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