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X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation
被引:9
|作者:
Su Cun-Jin
[1
,2
]
Xu Jian-Hao
[3
]
Liu Xu
[2
]
Zhao Feng-Lun
[1
]
Pan Jie
[1
]
Shi Ai-Ming
[1
]
Hu Duan-Min
[4
]
Yu Yun-Li
[5
]
Liu Tong
[2
,6
]
Zhang Yu-Song
[3
]
机构:
[1] Soochow Univ, Affiliated Hosp 2, Dept Pharm, Suzhou, Peoples R China
[2] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China
[3] Soochow Univ, Affiliated Hosp 2, Dept Oncol, Suzhou, Peoples R China
[4] Soochow Univ, Affiliated Hosp 2, Dept Gastroenterol, Suzhou, Peoples R China
[5] Soochow Univ, Affiliated Hosp 2, Dept Clin Pharmacol, Suzhou, Peoples R China
[6] Yanan Univ, Coll Life Sci, Yanan, Peoples R China
来源:
基金:
美国国家科学基金会;
关键词:
X-ray;
radiation;
pain;
transient receptor potential vanilloid 1;
transient receptor potential ankyrin 1;
dorsal root ganglion;
INDUCED PERIPHERAL NEUROPATHY;
ALPHA-LIPOIC ACID;
IONIZING-RADIATION;
PAIN;
RADIOTHERAPY;
CANCER;
STRESS;
SKIN;
IRRADIATION;
MANAGEMENT;
D O I:
10.1177/1744806919849201
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this study, mice were treated with 20 Gy X-ray to establish ionizing radiation-induced pain model. X-ray evoked a prolonged mechanical, heat, and cold allodynia in mice. Transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 were significantly upregulated in lumbar dorsal root ganglion. The mechanical and heat allodynia could be transiently reverted by intrathecal injection of transient receptor potential vanilloid 1 antagonist capsazepine and transient receptor potential ankyrin 1 antagonist HC-030031. Additionally, the phosphorylated extracellular regulated protein kinases (ERK) and Jun NH2-terminal Kinase (JNK) in pain neural pathway were induced by X-ray treatment. Our findings indicated that activation of transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1 is essential for the development of X-ray-induced allodynia. Furthermore, our findings suggest that targeting on transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 may be promising prevention strategies for X-ray-induced allodynia in clinical practice.
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页数:13
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