Nonsteroidal Anti-Inflammatory Drug-Induced Hepatoxicity

被引：37

作者：

Unzueta, Alberto ^{[1
]}

Vargas, Hugo E. ^{[2
]}

机构：

[1] Mayo Clin, Div Hosp Internal Med, Phoenix, AZ 85054 USA

[2] Mayo Clin, Div Hepatol, Phoenix, AZ 85054 USA

来源：

CLINICS IN LIVER DISEASE | 2013年 / 17卷 / 04期

关键词：

Nonsteroidal anti-inflammatory drugs; Drug-induced liver injury; Acute liver injury; Liver transplantation; Idiosyncratic hepatotoxicity; Hy's law; Drug safety; Drug surveillance; INDUCED LIVER-INJURY; THERAPEUTIC ARTHRITIS RESEARCH; RANDOMIZED CONTROLLED-TRIALS; FATAL CHOLESTATIC JAUNDICE; COX-2 SELECTIVE INHIBITORS; VANISHING BILE-DUCT; CHRONIC HEPATITIS-C; INDUCED HEPATOTOXICITY; UNITED-STATES; HYS LAW;

D O I：

10.1016/j.cld.2013.07.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Nonsteroidal anti-inflammatory drugs are among the most prescribed medications worldwide. After antibiotics and anticonvulsants they are considered the most common medications associated with drug-induced liver injury mainly through an idiosyncratic form of hepatotoxicity. In rare cases severe hepatotoxicity has been described with significant morbidity and mortality. Genetic risk factors have been reported with diclofenac and lumiracoxib. Postmarketing surveillance and monitoring is crucial to identify severe cases of hepatotoxicity.

引用

页码：643 / +

页数：15

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