A new triterpenoid from Verbena officinalis L.

被引：15
|
作者：
Shu, Ji-Cheng [1 ,2 ,3 ,4 ]
Liu, Jian-Qun [4 ]
Chou, Gui-Xin [1 ,2 ,3 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, MOE Key Lab Standardizat Chinese Med, Shanghai 201203, Peoples R China
[2] SATCM Key Lab New Resources & Qual Evaluat Chines, Shanghai 201203, Peoples R China
[3] Shanghai Key Lab Compound Chinese Med, Shanghai 201203, Peoples R China
[4] Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat Tradit Chinese Med, Nanchang 330006, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 14期
关键词：
Verbena officinalis; triterpenoids; antitumor; CONSTITUENTS; LEAVES;
D O I：
10.1080/14786419.2012.733391
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
To investigate the chemical constituents of Verbena officinalis L., five triterpenoid constituents were isolated and elucidated as 3,19,23-trihydroxyurs-12-en-28-oic acid, namely, 4-epi-barbinervic acid (1), 2,3-dihydroxyurs-12-en-28-oic acid (2), 3,24-dihydroxyurs-12-en- 28-oic acid (3), 3,24-dihydroxy-olean-12-en-28-oic acid (4), ursolic acid (5), using spectroscopic methods and comparing with published data. Compounds 2 and 4 were obtained from V. officinalis for the first time, and compound 1 is a new triterpenoid compound, which exhibits significantly higher antitumor activity against human hepatoma cell line Bel 7402 in vitro than the blank control.
引用
收藏
页码：1293 / 1297
页数：5
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