A convenient synthesis of a N-protected L-carbamoylpolyoxamic acid derivative:: Total synthesis of (+)-polyoxin J and (+)-polyoxin L

被引：0

作者：

Uchida, K ^{[1
]}

Kato, K ^{[1
]}

Akita, H ^{[1
]}

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan

来源：

SYNTHESIS-STUTTGART | 1999年 / 09期

关键词：

total synthesis; diastereoselective vinylation; polyoxamic acid; polyoxin J; polyoxin L;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient synthesis of the N-protected L-carbamoylpolyoxamic acid derivative 7 from 4-O-tert-butyldiphenylsilyl-2,3-isopropylidene-L-threose (8) using vinylmagnesium bromide and its application to the total syntheses of the peptidyl nucleoside antibiotics, polyoxins J (1) and L (2), are described.

引用

页码：1678 / 1686

页数：9

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