A convenient synthesis of a N-protected L-carbamoylpolyoxamic acid derivative:: Total synthesis of (+)-polyoxin J and (+)-polyoxin L

被引：0
|
作者：
Uchida, K [1 ]
Kato, K [1 ]
Akita, H [1 ]
机构：
[1] Toho Univ, Sch Pharmaceut Sci, Chiba 2748510, Japan
来源：
SYNTHESIS-STUTTGART | 1999年 / 09期
关键词：
total synthesis; diastereoselective vinylation; polyoxamic acid; polyoxin J; polyoxin L;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient synthesis of the N-protected L-carbamoylpolyoxamic acid derivative 7 from 4-O-tert-butyldiphenylsilyl-2,3-isopropylidene-L-threose (8) using vinylmagnesium bromide and its application to the total syntheses of the peptidyl nucleoside antibiotics, polyoxins J (1) and L (2), are described.
引用
收藏
页码：1678 / 1686
页数：9
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