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Molecular Profiling in Non-Squamous Non-Small Cell Lung Carcinoma: Towards a Switch to Next-Generation Sequencing Reflex Testing
被引:12
|作者:
Pujol, Nina
[1
]
Heeke, Simon
[2
]
Bontoux, Christophe
[3
,4
]
Boutros, Jacques
[4
,5
]
Ilie, Marius
[3
,4
]
Hofman, Veronique
[3
,4
]
Marquette, Charles-Hugo
[4
,5
]
Hofman, Paul
[3
,4
]
Benzaquen, Jonathan
[4
,5
]
机构:
[1] Cote dAzur Univ, Ctr Antoine Lacassagne, Dept Radiat Oncol, F-06000 Nice, France
[2] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA
[3] Cote dAzur Univ, Ctr Hosp Univ Nice, Lab Clin & Expt Pathol, Pasteur Hosp 1,FHU OncoAge, Biobank BB 0033 00025, F-06000 Nice, France
[4] Cote dAzur Univ, Inst Res Canc & Aging, INSERM U1081, CNRS,UMR 7284, F-06000 Nice, France
[5] Cote dAzur Univ, Ctr Hosp Univ Nice, Dept Pulm Med & Thorac Oncol, FHU OncoAge,Pasteur Hosp 1, F-06000 Nice, France
来源:
关键词:
next-generation sequencing;
predictive biomarker;
non-small cell lung carcinoma;
precision oncology;
OPEN-LABEL;
TARGETED THERAPY;
CANCER PATIENTS;
SOLID TUMORS;
FUSION;
MUTATION;
IMMUNOHISTOCHEMISTRY;
GENE;
CHEMOTHERAPY;
DRIVER;
D O I:
10.3390/jpm12101684
中图分类号:
R19 [保健组织与事业(卫生事业管理)];
学科分类号:
摘要:
Molecular diagnosis of lung cancer is a constantly evolving field thanks to major advances in precision oncology. The wide range of actionable molecular alterations in non-squamous non-small cell lung carcinoma (NS-NSCLC) and the multiplicity of mechanisms of resistance to treatment resulted in the need for repeated testing to establish an accurate molecular diagnosis, as well as to track disease evolution over time. While assessing the increasing complexity of the molecular composition of tumors at baseline, as well as over time, has become increasingly challenging, the emergence and implementation of next-generation sequencing (NGS) testing has extensively facilitated molecular profiling in NS-NSCLC. In this review, we discuss recent developments in the molecular profiling of NS-NSCLC and how NGS addresses current needs, as well as how it can be implemented to address future challenges in the management of NS-NSCLC.
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页数:14
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