Thrombopoietin receptor agonist switch in children with persistent and chronic severe immune thrombocytopenia: A retrospective analysis in a large tertiary center

被引：3
|
作者：
Suntsova, Elena, V [1 ]
Maschan, Alexey A. [1 ]
Baydildina, Dina D. [1 ]
Kalinina, Irina I. [1 ]
Petrova, Uliana N. [1 ]
Pshonkin, Alexey, V [1 ]
Novichkova, Galina A. [1 ]
机构：
[1] Dmitri Rogachev Natl Res Ctr Pediat Hematol Oncol, 1 Samory Mashela, Moscow 117997, Russia
来源：
PEDIATRIC BLOOD & CANCER | 2019年 / 66卷 / 06期
关键词：
children; eltrombopag; immune thrombocytopenia; romiplostim; thrombopoietin receptor agonists; ELTROMBOPAG; PURPURA; MULTICENTER; MANAGEMENT; RESISTANT;
D O I：
10.1002/pbc.27704
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We retrospectively analyzed sequential therapy with romiplostim and eltrombopag in 23 children with immune thrombocytopenia: switching from romiplostim to eltrombopag (10 patients) or vice versa (13 patients). The median age of patients at enrollment in the study was 5.6 years (2-15 years). Switching from romiplostim to eltrombopag was effective in eight (80%) patients, whereas switching from eltrombopag to romiplostim was effective in eight (62%) patients. The response rate was similar in patients failing the first thrombopoietin receptor agonist and those who had previous response. To date, all responders continue to maintain platelets over 50 x 10(9)/L at 13-39 months after switching.
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页数：4
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