Palladium-Catalyzed Allylation/Benzylation of H-Phosphinate Esters with Alcohols

被引：10

作者：

Fers-Lidou, Anthony ^{[1
]}

Berger, Olivier ^{[1
]}

Montchamp, Jean-Luc ^{[1
]}

机构：

[1] Texas Christian Univ, Dept Chem & Biochem, TCU Box 298860, Ft Worth, TX 76129 USA

来源：

MOLECULES | 2016年 / 21卷 / 10期

基金：

美国国家科学基金会;

关键词：

palladium; cross-coupling; alcohols; H-phosphinate esters; allylation; benzylation; P-STEREOGENIC COMPOUNDS; ALLYLIC ALCOHOLS; HYPOPHOSPHOROUS ACID; ESTERIFICATION; ALLYLATION;

D O I：

10.3390/molecules21101295

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Pd-catalyzed direct alkylation of H-phosphinic acids and hypophosphorous acid with allylic/benzylic alcohols has been described previously. Here, the extension of this methodology to H-phosphinate esters is presented. The new reaction appears general, although its scope is narrower than with the acids, and its mechanism is likely different. Various alcohols are examined in their reaction with phosphinylidene compounds (RRP)-R-1-P-2(O)H.

引用

页数：15

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