Investigation of metallodrug-protein interactions by size-exclusion chromatography coupled with inductively coupled plasma mass spectrometry (ICP-MS)

被引：93
|
作者：
Szpunar, J
Makarov, A
Pieper, T
Keppler, BK
Lobinski, R
机构：
[1] CNRS, F-64000 Pau, France
[2] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria
来源：
ANALYTICA CHIMICA ACTA | 1999年 / 387卷 / 02期
关键词：
platinum; ruthenium; antitumor drugs; speciation; SEC; ICP-MS; proteins;
D O I：
10.1016/S0003-2670(99)00074-4
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The coupling of size-exclusion HPLC with ICP-MS was developed for the studies of the kinetics of metallodrug binding to human serum proteins. Two platinum- and three ruthenium-based drugs were investigated. Various SEC columns (of different lengths and with different packings) were compared for the separation of the protein-bound and unbound fractions of a metallodrug prior to on-line detection of the metal (Ru or Pt). The approach developed offers considerable advantages over the methods based on ultrafiltration followed by the off-line metal determination in terms of speed, simplicity, precision and selectivity regarding the molecular weight of the complexes involved. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：135 / 144
页数：10
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