Water-soluble paclitaxel by conjugation to hyperbranched polyglycidols

被引：2
|
作者：
Huang, Xinhua [1 ]
Song, Ga Young [1 ]
Yu, Seong Jae [1 ]
Kim, Il [1 ]
机构：
[1] Pusan Natl Univ, Dept Polymer Sci & Engn, WCU Ctr Synthet Polymer Bioconjugate Hybrid Mat, Pusan 609735, South Korea
来源：
JOURNAL OF MATERIALS SCIENCE | 2013年 / 48卷 / 15期
关键词：
DRUG-DELIVERY; ANTINEOPLASTIC AGENT; BLOCK-COPOLYMER; TAXOL; MICELLES; DESIGN; NANOPARTICLES; DOXORUBICIN; WARFARIN; CARRIERS;
D O I：
10.1007/s10853-013-7302-0
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Chemical conjugates composed of paclitaxel (PTXL) and hyperbranched polyglycidols (HBP) were synthesized using glutaric anhydride as a "bridge" with esterification in dimethylformamide. A series of HBP-PTXL conjugates (HPCs) were synthesized using different molecular weights of HBP and varying ratios of HBP to PTXL, and they were characterized. An intact form of PTXL was regenerated from HPCs under acidic or basic pH conditions. Furthermore, water-soluble HPCs exhibit a more pronounced cytotoxic effect against cancer cells, suggesting that these HPCs can be utilized as tumor-specific therapeutic agents in the form of an injectable drug.
引用
收藏
页码：5163 / 5170
页数：8
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