Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin

被引：39
|
作者：
He, Zhongmei [1 ,3 ]
Tian, Yudan [2 ]
Zhang, Xiantao [3 ]
Bing, Bai [3 ]
Zhang, Lianxue [1 ]
Wang, Huaisheng [4 ]
Zhao, Wenjie [4 ]
机构：
[1] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130116, Peoples R China
[2] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China
[3] Xiuzheng Pharmaceut Grp Co Ltd, Changchun 130012, Peoples R China
[4] Jilin Tianyao Sci & Technol Co Ltd, Changchun 130012, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2012年 / 26卷 / 23期
基金：
中国国家自然科学基金;
关键词：
diosgenin; saponin; immunomodulation; anti-tumour activity;
D O I：
10.1080/14786419.2011.648192
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Diosgenin is a naturally occurring steroidal saponin abundantly present in many medical plants. In this study, diosgenin could significantly inhibit the growth of sarcoma-180 tumour cells in vivo, and remarkably increase thymus and spleen weights of S-180-bearing mice and upgrade the secretion level of TNF-alpha in serum. Moreover, diosgenin could stimulate lymphocyte transformation and enhance phagocytic capability of macrophages in vitro, and remarkably promoted the secretion of NO and TNF-alpha in macrophages. These results suggested that diosgenin could improve both specific and non-specific cellular immune responses, and the anti-tumour effects of diosgenin were achieved by immunostimulating properties instead of direct cytotoxicity.
引用
收藏
页码：2243 / 2246
页数：4
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