Effect of microwave irradiation on the synthesis of 1,2,4-triazol-3-one derivatives and their antimicrobial activities

被引：17
|
作者：
Kahveci, Bahittin [1 ]
Yilmaz, Fatih [2 ]
Mentese, Emre [2 ]
Beris, Fatih Saban [3 ]
机构：
[1] Karadeniz Tech Univ, Fac Hlth Sci, TR-61080 Trabzon, Turkey
[2] Recep Tayyip Erdogan Univ, Dept Chem, Art & Sci Fac, TR-53100 Rize, Turkey
[3] Recep Tayyip Erdogan Univ, Dept Biol, Art & Sci Fac, TR-53100 Rize, Turkey
来源：
JOURNAL OF CHEMICAL RESEARCH | 2012年 / 08期
关键词：
microwave irradiation; triazoles; 3,5-dichloroaniline; 1,3,4-oxadiazole; antimicrobial activity;
D O I：
10.3184/174751912X13400138806685
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An easy efficient method for the synthesis of N-(3,5-dichlorophenyl)-5-alkyl/aryl-3H-1,2,4-triazol-3-one derivatives under microwave irradiation has been developed using the reaction of 3,5-dichloroaniline and ethoxycarbonylhydrazones. This reaction occurs more efficiently and faster than the conventional heating method. We obtained 5-mercapto-1,3,4-oxadiazol derivatives by this method. The newly synthesised compounds have been tested for their antimicrobial activity against Enterobacter cloaceae, Escherichia coli, Klebsiella pneumonie, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella typhimurium, Yersinia pseudotuberculosis, Bacillus subtilis and Staphylococcus aereus.
引用
收藏
页码：484 / 488
页数：5
相关论文
共 50 条
  • [31] Kinetics of 2,4-dihydro-1,2,4-triazol-3-one nitration in nitric acid
    Zhilin, V. F.
    Zbarskii, V. L.
    Yudin, N. V.
    [J]. KINETICS AND CATALYSIS, 2006, 47 (06) : 846 - 849
  • [32] Synthesis and Evaluation of the Anticonvulsant Activity of 5-alkylthio-4-phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one Derivatives
    Zheng, Yan
    Deng, Xian-Qing
    Shu, Bing
    Wang, Shi-Ben
    Cao, Xu
    Quan, Zhe-Shan
    [J]. LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10 (06) : 543 - 549
  • [33] Kinetics of 2,4-dihydro-1,2,4-triazol-3-one nitration in nitric acid
    V. F. Zhilin
    V. L. Zbarskii
    N. V. Yudin
    [J]. Kinetics and Catalysis, 2006, 47 : 846 - 849
  • [34] Synthesis, In Vitro Antimicrobial and Antioxidant Activities of Some New 4,5-Dihydro-1H-1,2,4-triazol-5-one Derivatives
    Yuksek, Haydar
    Akyildirim, Onur
    Yola, Mehmet L.
    Gursoy-Kol, Ozlem
    Celebier, Mustafa
    Kart, Didem
    [J]. ARCHIV DER PHARMAZIE, 2013, 346 (06) : 470 - 480
  • [35] 4,5-DIHYDRO-5,5-DIMETHYL-3H-1,2,4-TRIAZOL-3-ONE 1-OXIDE
    KETTMANN, V
    SVETLIK, J
    SCHANTL, JG
    [J]. ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1995, 51 : 1133 - 1135
  • [36] From Nitro- to Heterocycle-Functionalized 1,2,4-Triazol-3-one Derivatives: Achieving High-Performance Insensitive Energetic Compounds
    Liu, Yuji
    Zeng, Zhiwei
    Huang, Wei
    Shreeve, Jean'ne M.
    Tang, Yongxing
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (06): : 4226 - 4231
  • [37] Microwave-promoted synthesis and biological activity of some 2-hetarylmethyl-4-(4-hetarylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives
    Ozil, Musa
    Bodur, Osman
    Ulker, Serdar
    Kahveci, Bahittin
    [J]. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2015, 51 (01) : 88 - 96
  • [38] Microwave-promoted synthesis and biological activity of some 2-hetarylmethyl-4-(4-hetarylphenyl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-one derivatives
    Musa Özil
    Osman Bodur
    Serdar Ülker
    Bahittin Kahveci
    [J]. Chemistry of Heterocyclic Compounds, 2015, 51 : 88 - 96
  • [39] Detection of 3-nitro-1,2,4-triazol-3-one (NTO) by surface-enhanced Raman spectroscopy
    Xu, Zhonghou
    Meng, Xiaoguang
    [J]. VIBRATIONAL SPECTROSCOPY, 2012, 63 : 390 - 395
  • [40] Synthesis and antimicrobial activities of some novel 1,2,4-triazole derivatives
    Mange, Yatin J.
    Isloor, Arun M.
    Malladi, Shridhar
    Isloor, Shrikrishna
    Fun, Hoong-Kun
    [J]. ARABIAN JOURNAL OF CHEMISTRY, 2013, 6 (02) : 177 - 181
12345