Cognitive deficits following brain tumor radiation therapy

被引：2

作者：

Buthut, M. ^{[1
,2
]}

Haussmann, R. ^{[2
]}

Seidlitz, A. ^{[3
,4
]}

Krause, M. ^{[3
,4
,5
,6
,7
,8
]}

Donix, M. ^{[2
,9
]}

机构：

[1] Stadt Klinikum Dresden, Neurol Klin Neustadt Trachau, Dresden, Germany

[2] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Klin & Poliklin Psychiat & Psychotherapie, Fetscherstr 74, D-01307 Dresden, Germany

[3] Tech Univ Dresden, Klin & Poliklin Strahlentherapie & Radioonkol, OncoRay Natl Zentrum Strahlenforsch Onkol, Med Fak, Dresden, Germany

[4] Tech Univ Dresden, Univ Klinikum Carl Gustav Carus, Dresden, Germany

[5] DKTK, Dresden, Germany

[6] NCT, Dresden, Germany

[7] Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany

[8] Helmholtz Zentrum Dresden Rossendorf, Inst Radioonkol OncoRay, Dresden, Germany

[9] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, Standort Dresden, Dresden, Germany

来源：

NERVENARZT | 2018年 / 89卷 / 04期

关键词：

Proton therapy; Radiotherapy dosage; Radiation effects; cognitive; Memory; Hippocampus; CENTRAL-NERVOUS-SYSTEM; LOW-GRADE GLIOMAS; QUALITY-OF-LIFE; NEUROCOGNITIVE FUNCTION IMPAIRMENT; PROTON THERAPY; CONVENTIONAL RADIOTHERAPY; CRANIAL IRRADIATION; CHILDHOOD-CANCER; ADULT SURVIVORS; PHASE-II;

D O I：

10.1007/s00115-017-0423-y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain radiation is an important treatment option for malignant and benign brain diseases. The possible acute or chronic impact of radiation therapy on cognitive performance is important for daily functioning and quality of life. A detailed evaluation of cognitive impairment is important in the context of how to control disease progression. The susceptibility of the hippocampus to radiation-induced neuronal damage and its important role in memory highlight that therapeutic strategies require precision medicine.

引用

页码：423 / 430

页数：8

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