Adult de novo acute myeloid leukemias with MLL rearrangements

被引：5
|
作者：
Bellido, MD [1 ]
Nomdedéu, JF [1 ]
机构：
[1] Hosp Santa Cruz & San Pablo, Dept Hematol, E-08025 Barcelona, Spain
来源：
LEUKEMIA RESEARCH | 1999年 / 23卷 / 06期
关键词：
MLL; leukemia; M2; Auer rods;
D O I：
10.1016/S0145-2126(99)00047-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MLL gene rearrangements identify a subgroup of acute leukemias with a bad prognosis. Fifty-one adult patients with de novo AML were screened for MLL rearrangements by Southern blot. An unexpected high frequency of AML-MZ according to the FAB classification was found. The most striking morphologic features of these cases were the scarcity of Auer rods and granulocytic dysplasia. Morphologic traits could be helpful in distinguishing molecular groups of AML-M2. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：585 / 588
页数：4
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