An evidence-based review of recent advances in therapy for heart failure with reduced ejection fraction (HFrEF)

被引：10

作者：

Raj, Leah ^{[1
]}

Adhyaru, Bhavin ^{[2
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, 49 Jesse Hill Jr Dr, Atlanta, GA 30303 USA

[2] Emory Univ, Sch Med, Dept Med, Div Gen Internal Med & Geriatr, Atlanta, GA USA

来源：

POSTGRADUATE MEDICAL JOURNAL | 2016年 / 92卷 / 1094期

关键词：

IN-HOSPITAL MORTALITY; NATRIURETIC PEPTIDE; RANDOMIZED-TRIAL; URODILATIN; INHIBITION; EPIDEMIOLOGY; ROSUVASTATIN; METAANALYSIS; COMBINATION; DYSFUNCTION;

D O I：

10.1136/postgradmedj-2016-134378

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An estimated 5.1 million Americans have chronic heart failure and this is expected to increase 25% by 2030. Heart failure is a clinical syndrome that evolves from either functional or structural changes to the ventricles that lead to filling or ejection abnormalities. Thus far, pharmacotherapy has been show to be beneficial in patients only with reduced ejection fraction; however, new therapies have been developed in hopes of reducing the burden of heart failure. In this review, we will discuss current pharmacotherapies recommended in American College of Cardiology/American Heart Association guidelines, the evidence behind these recommendations as well as new and emerging therapies that have been developed.

引用

页码：726 / 734

页数：9

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