Responsive Surfaces for Life Science Applications

被引:51
|
作者
Kuroki, Hidenori [1 ]
Tokarev, Ihor [1 ]
Minko, Sergiy [1 ]
机构
[1] Clarkson Univ, Dept Chem & Biomol Sci, Potsdam, NY 13699 USA
来源
ANNUAL REVIEW OF MATERIALS RESEARCH, VOL 42 | 2012年 / 42卷
基金
美国国家科学基金会;
关键词
stimuli-responsive polymers; self-assembled monolayers; protein adsorption; cell adhesion; biosensors; bioseparation membranes; SELF-ASSEMBLED MONOLAYERS; SPHERICAL POLYELECTROLYTE BRUSHES; PLASMON RESONANCE SPECTROSCOPY; MIXED-POLYMER BRUSHES; INTEGRIN-RGD BINDING; CELL-ADHESION; THERMORESPONSIVE POLYMER; PROTEIN ADSORPTION; ELECTROCHEMICAL DESORPTION; EXTRACELLULAR-MATRIX;
D O I
10.1146/annurev-matsci-070511-155044
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
This review describes recent developments in stimuli-responsive biointerfaces based on surface-tethered organic molecules, polymer chains, and polymer networks. The existing systems are classified according to the length scale of transformations occurring in the stimuli-responsive material and interactions of the material with the biological environment. In particular, two types of biointerfaces are considered: those whose interactions with proteins and cells can be switched reversibly or one time due to stimuli-triggered changes in molecular conformations or chemical bonds in functional molecules, and those that undergo reversible stimuli-triggered reconstruction at mesoscale due to stimuli-responsive phase behavior. Specific examples of stimuli-responsive surfaces from the recent literature are supplemented with discussion of potential biomedical applications.
引用
收藏
页码:343 / 372
页数:30
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