Neuregulin-1 (NRG-1) and its susceptibility to schizophrenia: a case-control study and meta-analysis

被引：12
|
作者：
Loh, Han Chern [1 ,2 ]
Tang, Pek Yee [3 ]
Tee, Shiau Foon [1 ]
Chow, Tze Jen [1 ]
Choong, Chee Yen [4 ]
Lim, Shen Yang [5 ]
Sen Yong, Hoi [6 ]
机构：
[1] Univ Tunku Abdul Rahman, FES, Dept Chem Engn, Kuala Lumpur 53300, Malaysia
[2] Univ Malaya, High Impact Res HIR Off, Kuala Lumpur 50603, Malaysia
[3] UTAR, FES, Dept Biomed Engn, Kuala Lumpur 53300, Malaysia
[4] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Environm & Nat Resource Sci, Bangi 43600, Selangor, Malaysia
[5] UM, Fac Med, Dept Med, Kuala Lumpur 50603, Malaysia
[6] UM, Fac Sci, Inst Biol Sci, Kuala Lumpur 50603, Malaysia
来源：
PSYCHIATRY RESEARCH | 2013年 / 208卷 / 02期
关键词：
Malaysian population; meta-analysis; NRG-1; AT-RISK HAPLOTYPE; ASSOCIATION; GENES;
D O I：
10.1016/j.psychres.2013.01.022
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Neuregulin-1 is widely investigated due to its hypothesised association with schizophrenia. Single-nucleotide polymorphisms rs764059, rs2954041 and rs3924999 were investigated (417 patients with schizophrenia and 429 controls). We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：186 / 188
页数：3
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