Bioactive products from marine micro- and macro-organsms

被引:50
|
作者
Kobayashi, J [1 ]
Tsuda, M [1 ]
Ishibashi, M [1 ]
机构
[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan
关键词
D O I
10.1351/pac199971061123
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A novel 37-membered macrolides, theonezolides A similar to C, and two novel manzamine-related alkaloids, nakadomarin A and ma'eganedin A, were isolated from Okinawan marine sponges, while three new polyhydroxyl compounds, luteophanols A similar to C, were obtained from a marine dinoflagellate. The structures were elucidated on the basis of the spectroscopic data. The absolute stereochemistry of the C-4 similar to C-17 fragment of theonezolides A similar to C was established by synthetic studies, and a plausible biogenetic path of nakadomarin A was proposed.
引用
收藏
页码:1123 / 1126
页数:4
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