Novel Metabotropic Glutamate Receptor 4 (mGlu4) Positive Allosteric Modulators For Multiple Sclerosis: in vitro and in vivo Pharmacological Characterization

被引:0
|
作者
Celanire, S. [1 ]
Mordant, C. [1 ]
Heroux, M. [1 ]
Royer-Urios, I. [1 ]
Orabona, C. [2 ]
Volpi, C. [2 ]
Mondanelli, G. [2 ]
Pallotta, M. T. [2 ]
Fallarino, F. [2 ]
Galibert, L. [1 ]
Poli, S. [1 ]
Grohmann, U. [2 ]
机构
[1] Addex Therapeut, CH-1228 Plan Les Ouates, Switzerland
[2] Univ Perugia, Dpt Expt Med & Biochem Sci, I-06126 Perugia, Italy
关键词
D O I
暂无
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
21
引用
收藏
页码:9 / 9
页数:1
相关论文
共 50 条
  • [31] Positive Allosteric Modulation of mGlu4 Receptors: Challenges and Opportunities
    Dale, E.
    Hong, H.
    Huang, X.
    Boyle, N. J.
    Collins, M. D.
    Tamm, J. A.
    Brodbeck, R. M.
    Zhong, H.
    Acher, F.
    Doller, D.
    CURRENT NEUROPHARMACOLOGY, 2014, 12 : 13 - 13
  • [32] The mGLU4 metabotropic glutamate receptor enhancer PHCCC: A novel inducer of peripheral immuno/inflammatory regulation in autoimmune EAE
    Di Marco, R.
    Fallarino, F.
    Notartomaso, S.
    Fazio, F.
    Volpi, C.
    Vacca, C.
    Scarselli, P.
    Battaglia, G.
    Bruno, V.
    Nicoletti, F.
    Grohmann, U.
    NEUROPHARMACOLOGY, 2008, 55 (04) : 594 - 594
  • [33] Discovery and Characterization of Novel Metabotropic Glutamate Receptor 4 (mGluR4) Allosteric Potentiators
    Celanire, S.
    Bolea, C.
    Brueckner, S.
    Liverton, N.
    Charvin, D.
    Hess, F.
    Poli, S.
    Bournique, B.
    Fonsi, M.
    Polsky-Fisher, S.
    Gibson, C.
    Girard, F.
    Browne, S.
    Dilella, A.
    Lis, E.
    Luo, B.
    Le Poul, E.
    Reynolds, I.
    Campo, B.
    CURRENT NEUROPHARMACOLOGY, 2011, 9 : 8 - 9
  • [34] Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
    Shuling Lin
    Shuo Han
    Xiaoqing Cai
    Qiuxiang Tan
    Kexiu Zhou
    Dejian Wang
    Xinwei Wang
    Juan Du
    Cuiying Yi
    Xiaojing Chu
    Antao Dai
    Yan Zhou
    Yan Chen
    Yu Zhou
    Hong Liu
    Jianfeng Liu
    Dehua Yang
    Ming-Wei Wang
    Qiang Zhao
    Beili Wu
    Nature, 2021, 594 : 583 - 588
  • [35] Solution-Phase Parallel Synthesis and SAR of Homopiperazinyl Analogs as Positive Allosteric Modulators of mGlu4
    Cheung, Yiu-Yin
    Zamorano, Rocio
    Blobaum, Anna L.
    Weaver, C. David
    Conn, P. Jeffrey
    Lindsley, Craig W.
    Niswender, Colleen M.
    Hopkins, Corey R.
    ACS COMBINATORIAL SCIENCE, 2011, 13 (02) : 159 - 165
  • [36] Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators as Novel Tools for in Vivo Investigation
    Keck, Thomas M.
    Zou, Mu-Fa
    Zhang, Peng
    Rutledge, Rebecca P.
    Newman, Amy Hauck
    ACS MEDICINAL CHEMISTRY LETTERS, 2012, 3 (07): : 544 - 549
  • [37] Structures of Gi-bound metabotropic glutamate receptors mGlu2 and mGlu4
    Lin, Shuling
    Han, Shuo
    Cai, Xiaoqing
    Tan, Qiuxiang
    Zhou, Kexiu
    Wang, Dejian
    Wang, Xinwei
    Du, Juan
    Yi, Cuiying
    Chu, Xiaojing
    Dai, Antao
    Zhou, Yan
    Chen, Yan
    Zhou, Yu
    Liu, Hong
    Liu, Jianfeng
    Yang, Dehua
    Wang, Ming-Wei
    Zhao, Qiang
    Wu, Beili
    NATURE, 2021, 594 (7864) : 583 - +
  • [38] Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor
    Rovira, Xavier
    Harrak, Youssef
    Trapero, Ana
    Gonzalez-Bulnes, Patricia
    Malhaire, Fanny
    Pin, Jean-Philippe
    Goudet, Cyril
    Giraldo, Jesus
    Llebaria, Amadeu
    CHEMMEDCHEM, 2014, 9 (12) : 2685 - 2698
  • [39] Design and synthesis of novel metabotropic glutamate receptor allosteric modulators
    Stankiewicz, Anna
    Bugno, Ryszard
    Branski, Piotr
    Bojarski, Andrzej J.
    PHARMACOLOGICAL REPORTS, 2012, 64 (02) : 473 - 474
  • [40] Design and synthesis of novel metabotropic glutamate receptor allosteric modulators
    Anna Stankiewicz
    Ryszard Bugno
    Piotr Brański
    Andrzej J. Bojarski
    Pharmacological Reports, 2012, 64 : 473 - 474