2-Iminothiolane as a Useful Coupling Reagent for Polyamine Solid-Phase Synthesis

被引：4

作者：

Hahn, Frank

Muellen, Klaus ^{[2
]}

Schepers, Ute ^{[1
]}

机构：

[1] Univ Bonn, LIMES, Inst Program Unit Membrane Biol & Lipid Biochem, D-53121 Bonn, Germany

[2] Max Planck Inst Polymer Res, D-55128 Mainz, Germany

来源：

SYNLETT | 2008年 / 18期

关键词：

solid-phase synthesis; chemoselectivity; conjugation; polyamines; 2-iminothiolane;

D O I：

10.1055/s-0028-1083566

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, the versatility of 2-iminothiolane to act as Coupling reagent for solid-phase synthesis of polyamine conjugates is shown. This method, which supersedes the use of elaborate protection group strategies, allows the mild Coupling of biomacromolecules and other functional moieties. Spermine conjugates with diverse maleimido building blocks were synthesized by a quick and selective reaction.

引用

页码：2785 / 2790

页数：6

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