Subunit-Dependent Postsynaptic Expression of Kainate Receptors on Hippocampal Interneurons in Area CA1

被引:25
|
作者
Wondolowski, Joyce
Frerking, Matthew [1 ]
机构
[1] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Beaverton, OR 97006 USA
来源
JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 02期
基金
美国国家卫生研究院;
关键词
kainic acid; hippocampus; interneurons; synaptic; glutamate receptor; glutamate transporters; MOSSY-FIBER SYNAPSES; AMPA RECEPTORS; SYNAPTIC-TRANSMISSION; PYRAMIDAL CELLS; THALAMOCORTICAL SYNAPSES; MULTIVESICULAR RELEASE; FEEDFORWARD INHIBITION; EXCITATORY SYNAPSES; GAMMA-OSCILLATIONS; BIPOLAR CELLS;
D O I
10.1523/JNEUROSCI.4788-08.2009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Kainate receptors (KARs) contribute to postsynaptic excitation in only a select subset of neurons. To define the parameters that specify the postsynaptic expression of KARs, we examined the contribution of KARs to EPSCs on hippocampal interneurons in area CA1. Interneurons in stratum radiatum/lacunosum-moleculare express KARs both with and without the GluR5 subunit, but KAR-mediated EPSCs are generated mainly, if not entirely, by GluR5-containing KARs. Extrasynaptic glutamate spillover profoundly recruits AMPA receptors (AMPARs) with little effect on KARs, indicating that KARs are targeted at the synapse more precisely than AMPARs. However, spontaneous EPSCs with a conventional AMPAR component did not have a resolvable contribution of KARs, suggesting that the KARs that contribute to the evoked EPSCs are at a distinct set of synapses. GluR5-containing KARs on interneurons in stratum oriens do not contribute substantially to the EPSC. We conclude that KARs are localized to synapses by cell type-, synapse-, and subunit-selective mechanisms.
引用
收藏
页码:563 / 574
页数:12
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