2,1-Benzothiazine 2,2-Dioxides. 1. Synthesis, Structure, and Analgesic Activity of 1-R-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylic Acid Esters

被引：25
|
作者：
Ukrainets, I. V. [1 ]
Petrushova, L. A. [1 ]
Dzyubenko, S. P. [2 ]
机构：
[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine
[2] Vinnitsa NI Pirogov Natl Med Univ, UA-21018 Vinnitsa, Ukraine
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 09期
关键词：
2,1-benzothiazines; esters; acylation; analgesic activity; heterocyclization; RING;
D O I：
10.1007/s10593-013-1388-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A preparative method for the synthesis of a series of 1-R-4-hydroxy-2,2-dioxo-1H-2 lambda(6),1-benzothiazine-3-carboxylates has been developed. The special features of the steric structure for compounds of this class have been studied on the example of the 1-N-methyl derivative. Results of studying the analgesic properties of the substances obtained are given.
引用
收藏
页码：1378 / 1383
页数：6
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