2,1-Benzothiazine 2,2-Dioxides. 1. Synthesis, Structure, and Analgesic Activity of 1-R-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylic Acid Esters

被引：25

作者：

Ukrainets, I. V. ^{[1
]}

Petrushova, L. A. ^{[1
]}

Dzyubenko, S. P. ^{[2
]}

机构：

[1] Natl Univ Pharm, UA-61002 Kharkov, Ukraine

[2] Vinnitsa NI Pirogov Natl Med Univ, UA-21018 Vinnitsa, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2013年 / 49卷 / 09期

关键词：

2,1-benzothiazines; esters; acylation; analgesic activity; heterocyclization; RING;

D O I：

10.1007/s10593-013-1388-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A preparative method for the synthesis of a series of 1-R-4-hydroxy-2,2-dioxo-1H-2 lambda(6),1-benzothiazine-3-carboxylates has been developed. The special features of the steric structure for compounds of this class have been studied on the example of the 1-N-methyl derivative. Results of studying the analgesic properties of the substances obtained are given.

引用

页码：1378 / 1383

页数：6

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