Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report

被引：8

作者：

Oldoni, Emanuela ^{[1
]}

Saunders, Gary ^{[1
]}

Bietrix, Florence ^{[1
]}

Garcia Bermejo, Maria Laura ^{[2
]}

Niehues, Anna ^{[3
,4
]}

't Hoen, Peter A. C. ^{[4
]}

Nordlund, Jessica ^{[5
]}

Hajduch, Marian ^{[6
,7
]}

Scherer, Andreas ^{[8
]}

Kivinen, Katja ^{[8
,9
,10
]}

Pitkanen, Esa ^{[8
,9
,10
]}

Makela, Tomi Pekka ^{[9
,10
]}

Gut, Ivo ^{[11
]}

Scollen, Serena ^{[12
]}

Kozera, Lukasz ^{[13
]}

Esteller, Manel ^{[14
,15
,16
,17
]}

Shi, Leming ^{[18
,19
]}

Ussi, Anton ^{[1
]}

Andreu, Antonio L. ^{[1
]}

van Gool, Alain J. ^{[3
]}

机构：

[1] European Infrastruct Translat Med EATRIS, Amsterdam, Netherlands

[2] Ramon y Cajal Hlth Res Inst IRYCIS, Biomarkers & Therapeut Targets Grp, Madrid, Spain

[3] Radboud Univ Nijmegen, Translat Metabol Lab, Dept Lab Med, Radboud Inst Mol Life Sci,Med Ctr, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Ctr Mol & Biomol Informat, Radboud Inst Mol Life Sci, Med Ctr, Nijmegen, Netherlands

[5] Uppsala Univ, Dept Med Sci, Mol Precis Med & Sci Life Lab, Uppsala, Sweden

[6] Palacky Univ, Inst Mol & Translat Med, Fac Med & Dent, Olomouc, Czech Republic

[7] Univ Hosp Olomouc, Olomouc, Czech Republic

[8] Universityof Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland

[9] Univ Helsinki, iCAN Digital Precis Canc Med Flagship, Helsinki, Finland

[10] Univ Helsinki, HiLIFE Helsinki Inst Life Sci, Helsinki, Finland

[11] Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Barcelona, Spain

[12] ELIXIR Hub, Hinxton, England

[13] Biobanking & BioMol Resources Res Infrastruct Eur, Graz, Austria

[14] Josep Carreras Leukemia Res Inst IJC, Badalona, Spain

[15] Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain

[16] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain

[17] Univ Barcelona UB, Sch Med & Hlth Sci, Physiol Sci Dept, Barcelona, Spain

[18] Fudan Univ, State Key Lab Genet Engn, Sch Life Sci, Shanghai, Peoples R China

[19] Fudan Univ, Human Phenome Inst, Shanghai, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2022年 / 9卷

基金：

欧盟地平线“2020”;

关键词：

personalised medicine; translational medicine; multi-omics; EU initiatives; research infrastructures; bottlenecks in health data; DATA INTEGRATION; RECOMMENDATIONS; MANAGEMENT; HEALTH; GENE;

D O I：

10.3389/fmolb.2022.974799

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Personalised medicine (PM) presents a great opportunity to improve the future of individualised healthcare. Recent advances in -omics technologies have led to unprecedented efforts characterising the biology and molecular mechanisms that underlie the development and progression of a wide array of complex human diseases, supporting further development of PM. This article reflects the outcome of the 2021 EATRIS-Plus Multi-omics Stakeholder Group workshop organised to 1) outline a global overview of common promises and challenges that key European stakeholders are facing in the field of multi-omics research, 2) assess the potential of new technologies, such as artificial intelligence (AI), and 3) establish an initial dialogue between key initiatives in this space. Our focus is on the alignment of agendas of European initiatives in multi-omics research and the centrality of patients in designing solutions that have the potential to advance PM in long-term healthcare strategies.

引用

页数：11

共 27 条

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