Concentration dependence of the osmotic and activity coefficients of imipramine and clomipramine hydrochlorides in aqueous solution

被引：28

作者：

Taboada, P

Attwood, D

Ruso, JM

Suárez, MJ

Sarmiento, F

Mosquera, V ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Fis, Dept Fis Aplicada & Fis Mat, Grp Fis Coloides & Polimeros, E-15706 Santiago, Spain

[2] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 1999年 / 44卷 / 04期

关键词：

D O I：

10.1021/je990060o

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Vapor pressure lowering of the two antidepressant drugs imipramine and clomipramine hydrochloride solutions in the concentration range 0-0.28 mol.kg(-1) at 303.15 K were determined. For imipramine hydrochloride, measurements at 308.15 and 313.15 K were also made. From these results, the osmotic and activity coefficients for both compounds were calculated, and their concentration dependence was studied. An inflection point was detected for each substance, identified as a critical concentration.

引用

页码：820 / 822

页数：3

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