AMP-activated protein kinase isoenzyme family: Subunit structure and chromosomal location

被引：107
|
作者：
Stapleton, D
Woollatt, E
Mitchelhill, KI
Nicholl, JK
Fernandez, CS
Michell, BJ
Witters, LA
Power, DA
Sutherland, GR
Kemp, BE
机构：
[1] ST VINCENTS HOSP, ST VINCENTS INST MED RES, FITZROY, VIC 3065, AUSTRALIA
[2] ST VINCENTS HOSP, DEPT CLIN IMMUNOL, FITZROY, VIC 3065, AUSTRALIA
[3] DARTMOUTH COLL SCH MED, DEPT MED, DIV ENDOCRINOL & METAB, HANOVER, NH 03755 USA
[4] DARTMOUTH COLL SCH MED, DEPT BIOCHEM, HANOVER, NH 03755 USA
[5] MOL GENET WOMENS & CHILDRENS HOSP, DEPT CYTOGENET, CTR GENET MED, ADELAIDE, SA 5006, AUSTRALIA
来源：
FEBS LETTERS | 1997年 / 409卷 / 03期
关键词：
AMP-activated protein kinase; isoform; gene; chromosome;
D O I：
10.1016/S0014-5793(97)00569-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma(38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha 2 isoform catalytic subunit is associated with beta 1 and gamma 1 and not beta 2 or gamma 2 subunit isoforms. The beta 1 and gamma 1 isoforms are also subunits of the alpha 1 isoform. The sequence of cloned human AMPK-beta 1 is 95% identical in amino acid sequence with rat beta 1. Human chromosomal localizations were determined for AMPK-alpha 1 (5p11-p14), AMPK-beta 1 (12q24.1-24.3) and AMPK-gamma 1 (12q12-q14), respectively. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：452 / 456
页数：5
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