AMP-activated protein kinase isoenzyme family: Subunit structure and chromosomal location

被引：107
|
作者：
Stapleton, D
Woollatt, E
Mitchelhill, KI
Nicholl, JK
Fernandez, CS
Michell, BJ
Witters, LA
Power, DA
Sutherland, GR
Kemp, BE
机构：
[1] ST VINCENTS HOSP, ST VINCENTS INST MED RES, FITZROY, VIC 3065, AUSTRALIA
[2] ST VINCENTS HOSP, DEPT CLIN IMMUNOL, FITZROY, VIC 3065, AUSTRALIA
[3] DARTMOUTH COLL SCH MED, DEPT MED, DIV ENDOCRINOL & METAB, HANOVER, NH 03755 USA
[4] DARTMOUTH COLL SCH MED, DEPT BIOCHEM, HANOVER, NH 03755 USA
[5] MOL GENET WOMENS & CHILDRENS HOSP, DEPT CYTOGENET, CTR GENET MED, ADELAIDE, SA 5006, AUSTRALIA
来源：
FEBS LETTERS | 1997年 / 409卷 / 03期
关键词：
AMP-activated protein kinase; isoform; gene; chromosome;
D O I：
10.1016/S0014-5793(97)00569-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma(38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha 2 isoform catalytic subunit is associated with beta 1 and gamma 1 and not beta 2 or gamma 2 subunit isoforms. The beta 1 and gamma 1 isoforms are also subunits of the alpha 1 isoform. The sequence of cloned human AMPK-beta 1 is 95% identical in amino acid sequence with rat beta 1. Human chromosomal localizations were determined for AMPK-alpha 1 (5p11-p14), AMPK-beta 1 (12q24.1-24.3) and AMPK-gamma 1 (12q12-q14), respectively. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：452 / 456
页数：5
相关论文
共 50 条
  • [1] Structure and function of AMP-activated protein kinase
    Oakhill, J. S.
    Scott, J. W.
    Kemp, B. E.
    ACTA PHYSIOLOGICA, 2009, 196 (01) : 3 - 14
  • [2] AMP-Activated Protein Kinase: Structure and Regulation
    Sanz, Pascual
    CURRENT PROTEIN & PEPTIDE SCIENCE, 2008, 9 (05) : 478 - 492
  • [3] An activating mutation in the γ1 subunit of the AMP-activated protein kinase
    Hamilton, SR
    Stapleton, D
    O'Donnell, JB
    Kung, JT
    Dalal, SR
    Kemp, BE
    Witters, LA
    FEBS LETTERS, 2001, 500 (03) : 163 - 168
  • [4] Investigation of amp-activated protein kinase gamma subunit isoforms
    Jarvie, S
    Bayliss, J
    Carling, D
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2001, 33 (06) : A170 - A170
  • [5] Regulation of AMP-activated protein kinase by a pseudosubstrate sequence on the γ subunit
    Scott, John W.
    Ross, Fiona A.
    Liu, J. K. David
    Hardie, D. Grahame
    EMBO JOURNAL, 2007, 26 (03): : 806 - 815
  • [6] Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
    Cheung, PCF
    Salt, IP
    Davies, SP
    Hardie, DG
    Carling, D
    BIOCHEMICAL JOURNAL, 2000, 346 : 659 - 669
  • [7] AMP-activated protein kinase kinase:: detection with recombinant AMPK α1 subunit
    Hamilton, SR
    O'Donnell, JB
    Hammet, A
    Stapleton, D
    Habinowski, SA
    Means, AR
    Kemp, BE
    Witters, LA
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 293 (03) : 892 - 898
  • [8] Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase
    Lipovka, Yulia
    Chen, Hao
    Vagner, Josef
    Price, Theodore J.
    Tsao, Tsu-Shuen
    Konhilas, John P.
    BIOSCIENCE REPORTS, 2015, 35
  • [9] Cloning and expression of chicken AMP-activated protein kinase subunit genes
    Proszkowiec-Weglarz, M.
    Richards, M. P.
    Poch, S. M.
    POULTRY SCIENCE, 2006, 85 : 75 - 75
  • [10] Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
    Crute, BE
    Seefeld, K
    Gamble, J
    Kemp, BE
    Witters, LA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (52) : 35347 - 35354
12345