Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Amicable for Automation

被引：1
|
作者：
Kavitha, Mitta [1 ]
Mahipal, Bodugam [1 ]
Mainkar, Prathama S. [1 ]
Chandrasekhar, Srivari [1 ]
机构：
[1] CSIR Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India
来源：
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2013年 / 16卷 / 08期
关键词：
Alkynes; azides; Suzuki reaction; Triazoles; 3+2]-cycloaddition; CROSS-COUPLING REACTIONS; ORGANIC AZIDES; CYCLOADDITION REACTIONS; CLICK CHEMISTRY; ALKYNES; PALLADIUM;
D O I：
10.2174/1386207311316080009
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A three-component 3+2 cycloaddition reaction followed by Suzuki coupling reaction was carried out to synthesize a library of compounds using automation (parallel synthesizer). Scaffolds that are unexplored in literature were used for the synthesis of library. The iodo-triazoles formed by 3+2 cycloaddition reaction were coupled with boronic acids to get tri-substituted triazoles.
引用
收藏
页码：657 / 663
页数：7
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