RETRACTED: FOXO3 A master switch for regulating tolerance and immunity in dendritic cells (Retracted article. See vol. 5, 2016)

被引：21

作者：

Watkins, Stephanie K. ^{[1
]}

Hurwitz, Arthur A. ^{[1
]}

机构：

[1] NCI, Tumor Immun & Tolerance Sect, Lab Mol Immunoregulat, Canc & Inflammat Program, Frederick, MD 21701 USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 02期

关键词：

tumor; dendritic cells; tolerance; Foxo3; immunotherapy; PROSTATIC TUMORS; T-CELLS; TRANSCRIPTION; SUPPRESSOR;

D O I：

10.4161/onci.1.2.18241

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent findings demonstrate that dendritic cells in prostate tumors induce immune tolerance in tumor antigen-specific CD8(+) T cells. We propose that DC tolerogenicity can be regulated by expression of Foxo3; silencing Foxo3 expression enhances anti-tumor immune responses and renders FOXO3 a potential target for immunotherapy.

引用

页码：252 / 254

页数：3

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