Responsiveness of naive CD4 T cells to polarizing cytokine determines the ratio of Th1 and Th2 cell differentiation

被引：33

作者：

Mikhalkevich, N

Becknell, B

Caligiuri, MA

Bates, MD

Harvey, R

Zheng, WP

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Microbiol & Immunol,Aab Inst Biomed Sci, David H Smith Ctr Vaccine Biol & Immunol, Rochester, NY 14642 USA

[2] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[3] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp, Med Ctr,Fiv Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA

[4] St Vincents Hosp, Victor Chang Cardiac Res Inst, Darlinghurst, NSW 2010, Australia

[5] Univ New S Wales, Fac Med & Life Sci, Kensington, NSW 2033, Australia

来源：

JOURNAL OF IMMUNOLOGY | 2006年 / 176卷 / 03期

关键词：

D O I：

10.4049/jimmunol.176.3.1553

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intrinsic features of naive CD4 T cells that affect their ability to respond to polarizing signals for Th cell differentiation are not well understood. In this study, we show that naive CD4 T cells from mice transgenic for the Hlx gene expressed lower levels of IL-4R alpha. The down-regulation of IL-4R alpha diminished IL-4 signaling and the Th2 response and enhanced the Th1 response under suboptimal polarizing conditions. In nontransgenic CD4 T cells, blocking IL-4R alpha with Abs had the same effect in an Ab dose-dependent manner. Conversely, Hlx haploinsufficiency caused higher expression of IL-4R alpha to favor Th2 cell differentiation. Thus, the IL-4Ra level on naive CD4 T cells is genetically controlled by Hlx and determines the ratio of Th1 and Th2 cell differentiation.

引用

页码：1553 / 1560

页数：8

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