Alzheimer's Disease-Related Lesions

被引：4
|
作者：
Alafuzoff, Irina [1 ,2 ,3 ]
机构：
[1] Uppsala Univ, Dept Immunol Genet & Pathol, S-75185 Uppsala, Sweden
[2] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio, Finland
[3] Univ Uppsala Hosp, Dept Clin Pathol & Cytol, Uppsala, Sweden
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2013年 / 33卷
关键词：
Aging; Alzheimer's disease-related pathology; amyloid-beta; co-morbidity; hyperphosphorylated tau; immunohistochemistry; neuropathology; alpha-synuclein; BRAINNET EUROPE CONSORTIUM; LEWY BODIES; NEUROFIBRILLARY PATHOLOGY; NEUROPATHOLOGIC ASSESSMENT; PARKINSONS-DISEASE; APOLIPOPROTEIN-E; ALPHA-SYNUCLEIN; DIAGNOSIS; DEMENTIA; PLAQUES;
D O I：
10.3233/JAD-2012-129024
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The invitation to contribute to "Alzheimer's Disease: Advances for a New Century" gave me an opportunity to briefly summarize my personal opinions about how the field of neuropathology has evolved. The goal is to briefly exemplify the changes that have influenced the way we conduct our diagnostic work as well as the way we interpret our results. From an era of histological stains, we have moved to visualization of altered proteins in predicted brain regions; we have also realized that in many aged subjects, not one but a plethora of co-pathologies are seen, and finally, we have become aware that the degenerative process is initiated much earlier than we ever suspected.
引用
收藏
页码：S173 / S179
页数：7
相关论文
共 50 条
  • [41] Tau acts as a mediator for Alzheimer's disease-related synaptic deficits
    Liao, Dezhi
    Miller, Eric C.
    Teravskis, Peter J.
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2014, 39 (07) : 1202 - 1213
  • [42] Alzheimer's disease-related transcriptional sex differences in myeloid cells
    Coales, Isabelle
    Tsartsalis, Stergios
    Fancy, Nurun
    Weinert, Maria
    Clode, Daniel
    Owen, David
    Matthews, Paul M.
    [J]. JOURNAL OF NEUROINFLAMMATION, 2022, 19 (01)
  • [43] African ancestry protects against Alzheimer's disease-related neuropathology
    D Schlesinger
    L T Grinberg
    J G Alba
    M S Naslavsky
    L Licinio
    J M Farfel
    C K Suemoto
    R E de Lucena Ferretti
    R E P Leite
    M P de Andrade
    A C F dos Santos
    H Brentani
    C A Pasqualucci
    R Nitrini
    W Jacob-Filho
    M Zatz
    [J]. Molecular Psychiatry, 2013, 18 : 79 - 85
  • [44] Alzheimer's Disease-Related Protein Expression in the Retina of Octodon degus
    Du, Lucia Y.
    Chang, Lily Y-L.
    Ardiles, Alvaro O.
    Tapia-Rojas, Cheril
    Araya, Joaquin
    Inestrosa, Nibaldo C.
    Palacios, Adrian G.
    Acosta, Monica L.
    [J]. PLOS ONE, 2015, 10 (08):
  • [45] Alzheimer’s disease-related transcriptional sex differences in myeloid cells
    Isabelle Coales
    Stergios Tsartsalis
    Nurun Fancy
    Maria Weinert
    Daniel Clode
    David Owen
    Paul M. Matthews
    [J]. Journal of Neuroinflammation, 19
  • [46] Human Brain and Blood N-Glycome Profiling in Alzheimer's Disease and Alzheimer's Disease-Related Dementias
    Yu, Lei
    Huo, Zhiguang
    Yang, Jingyun
    Palma-Gudiel, Helena
    Boyle, Patricia A.
    Schneider, Julie A.
    Bennett, David A.
    Zhao, Jinying
    [J]. FRONTIERS IN AGING NEUROSCIENCE, 2021, 13
  • [47] Gene Expression of Disease-related Genes in Alzheimer's Disease is Impaired by Tau Aggregation
    Siano, G.
    Varisco, M.
    Scarlatti, A.
    Caiazza, M. C.
    Dunville, K.
    Cremisi, F.
    Costa, M.
    Pancrazi, L.
    Di Primio, C.
    Cattaneo, A.
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 2020, 432 (24)
  • [48] Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis
    Suzuki, Toshiharu
    Araki, Yoichi
    Yamamoto, Tohru
    Nakaya, Tadashi
    [J]. JOURNAL OF BIOCHEMISTRY, 2006, 139 (06): : 949 - 955
  • [49] Apolipoprotein E-Dependent Accumulation of Alzheimer Disease-Related Lesions Begins in Middle Age
    Kok, Eloise
    Haikonen, Satu
    Luoto, Teemu
    Huhtala, Heini
    Goebeler, Sirkka
    Haapasalo, Hannu
    Karhunen, Pekka J.
    [J]. ANNALS OF NEUROLOGY, 2009, 65 (06) : 650 - 657
  • [50] Alzheimer Disease-Related - Related Biomarkers in Patients on Maintenance Hemodialysis
    Masurkar, Arjun, V
    Bansal, Nisha
    Prince, David K.
    Winkelmayer, Wolfgang C.
    Ortiz, Daniela F.
    Ramos, Gianna
    Soomro, Qandeel
    Vedvyas, Alok
    Osorio, Ricardo S.
    Bernard, Mark A.
    Debure, Ludovic
    Ahmed, Wajiha
    Boutajangout, Allal
    Wisniewski, Thomas
    Charytan, David M.
    [J]. KIDNEY MEDICINE, 2024, 6 (11)
12345