Allyl end-functionalized poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymers:: Synthesis, characterization, and chemical modification

被引：11
|
作者：
Studer, P
Breton, P
Riess, G
机构：
[1] Ecole Natl Super Chim, Inst Chim Surfaces & Interfaces, Lab Chim Macromol, F-68200 Mulhouse, France
[2] HALISOL, F-75116 Paris, France
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2005年 / 206卷 / 24期
关键词：
anionic polymerization; diblock copolymers; drug delivery systems; functionalization of polymers; micelles;
D O I：
10.1002/macp.200500362
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Poly(ethylene oxide)-block-poly(methylidene malonate 2.1.2) block copolymer (PEO-b-PMM 2.1.2) bearing an allyl moiety at the poly(ethylene oxide) chain end was synthesized by sequential anionic polymerization of ethylene oxide (EO) and methylidene malonate 2.1.2 (MM 2.1.2). This allyl functional group was subsequently modified by reaction with thiol-bearing functional groups to generate carboxyl and amino functionalized biodegradable block copolymers. These end-group reactions, performed in good yields both in organic media and in aqueous micellar solutions, lead to functionalized PEO-b-PMM 2.1.2 copolymers which are of interest for cell targeting purposes.
引用
收藏
页码：2461 / 2469
页数：9
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