Effect of functionalization on drug delivery potential of carbon nanotubes

被引：23
|
作者：
Sharma, Sonam [1 ]
Mehra, Neelesh Kumar [1 ]
Jain, Keerti [1 ]
Jain, Narendra Kumar [1 ]
机构：
[1] ISF Coll Pharm, Dept Pharmaceut Sci, Pharmaceut Res Lab, Moga 142001, India
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 08期
关键词：
carbon nanotubes; cellular trafficking; characterization; functionalization; TARGETED DELIVERY; CANCER-CELLS; DOXORUBICIN;
D O I：
10.3109/21691401.2015.1111227
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The main aim of the present investigation was to explore the effect of functionalization on drug delivery potential of carbon nanotubes (CNTs) and to compare the in vitro and in vivo cancer targeting potential of doxorubicin HCL (DOX)-loaded ox-/multi-walled CNTs (MWCNTs), DOX-loaded PEG-MWCNTs and DOX-loaded FA-PEG-MWCNTs. The DOX/PEG-FA-MWCNTs showed enhanced cytotoxicity and were most preferentially taken up by the cancerous cells. The obtained results also support the extended resistance time and sustained release profile of drug-loaded surface-engineered MWCNTs. Overall, we concluded that the developed MWCNTs nanoformulations have higher cancer targeting potential.
引用
收藏
页码：1851 / 1860
页数：10
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