Effect of functionalization on drug delivery potential of carbon nanotubes

被引：23

作者：

Sharma, Sonam ^{[1
]}

Mehra, Neelesh Kumar ^{[1
]}

Jain, Keerti ^{[1
]}

Jain, Narendra Kumar ^{[1
]}

机构：

[1] ISF Coll Pharm, Dept Pharmaceut Sci, Pharmaceut Res Lab, Moga 142001, India

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 08期

关键词：

carbon nanotubes; cellular trafficking; characterization; functionalization; TARGETED DELIVERY; CANCER-CELLS; DOXORUBICIN;

D O I：

10.3109/21691401.2015.1111227

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The main aim of the present investigation was to explore the effect of functionalization on drug delivery potential of carbon nanotubes (CNTs) and to compare the in vitro and in vivo cancer targeting potential of doxorubicin HCL (DOX)-loaded ox-/multi-walled CNTs (MWCNTs), DOX-loaded PEG-MWCNTs and DOX-loaded FA-PEG-MWCNTs. The DOX/PEG-FA-MWCNTs showed enhanced cytotoxicity and were most preferentially taken up by the cancerous cells. The obtained results also support the extended resistance time and sustained release profile of drug-loaded surface-engineered MWCNTs. Overall, we concluded that the developed MWCNTs nanoformulations have higher cancer targeting potential.

引用

页码：1851 / 1860

页数：10

共 50 条

[1] The Effect of Optimization HCl Addition to Dispersibility in Carbon Nanotubes Functionalization as Drug Delivery
Wulan, P. P. D. K.
Permana, G.
Putri, W. A.
[J]. 4TH INTERNATIONAL TROPICAL RENEWABLE ENERGY CONFERENCE (I-TREC 2019), 2020, 2255
[2] Nanotechnology and carbon nanotubes; A review of potential in drug delivery
Edwin Kamalha
Xiangyang Shi
Josphat I. Mwasiagi
Yongchun Zeng
[J]. Macromolecular Research, 2012, 20 : 891 - 898
[3] Carbon nanotubes buckypapers for potential transdermal drug delivery
Schwengber, Alex
Prado, Hector J.
Zilli, Dario A.
Bonelli, Pablo R.
Cukierman, Ana L.
[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 57 : 7 - 13
[4] Nanotechnology and carbon nanotubes; A review of potential in drug delivery
Kamalha, Edwin
Shi, Xiangyang
Mwasiagi, Josphat I.
Zeng, Yongchun
[J]. MACROMOLECULAR RESEARCH, 2012, 20 (09) : 891 - 898
[5] The effect of hydrochloric acid addition to increase carbon nanotubes dispersibility as drug delivery system by covalent functionalization
Wulan, P. P. D. K.
Ulwani, S. H.
Wulandari, H.
Purwanto, W. W.
Mulia, K.
[J]. QUALITY IN RESEARCH: INTERNATIONAL SYMPOSIUM ON MATERIALS, METALLURGY, AND CHEMICAL ENGINEERING, 2018, 316
[6] Reciprocal effects of the chirality and the surface functionalization on the drug delivery permissibility of carbon nanotubes
Skandani, Amir Alipour
Al-Haik, Marwan
[J]. SOFT MATTER, 2013, 9 (48) : 11645 - 11649
[7] Carbon nanotubes as potential material for drug delivery—experiment and simulation
Artur P. Terzyk
Marek Wiśniewski
Katarzyna Dulska
Agnieszka Bielicka
Piotr A. Gauden
Sylwester Furmaniak
Karolina Werengowska-Ciećwierz
[J]. Adsorption, 2013, 19 : 269 - 272
[8] Organic functionalization of single-walled carbon nanotubes (SWCNTs) with some chemotherapeutic agents as a potential method for drug delivery
Khazaei, Ardeshir
Rad, Mohammad Navid Soltani
Borazjani, Maryam Kiani
[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2010, 5 : 639 - 645
[9] COVALENT FUNCTIONALIZATION OF SINGLE WALLED CARBON NANOTUBES WITH DOXORUBICIN FOR CONTROLLED DRUG DELIVERY SYSTEMS
Ciobotaru, C. C.
Damian, C. M.
Polosan, S.
Matei, E.
Iovu, H.
[J]. DIGEST JOURNAL OF NANOMATERIALS AND BIOSTRUCTURES, 2014, 9 (01) : 413 - 422
[10] Carbon nanotubes as potential material for drug delivery-experiment and simulation
Terzyk, Artur P.
Wisniewski, Marek
Dulska, Katarzyna
Bielicka, Agnieszka
Gauden, Piotr A.
Furmaniak, Sylwester
Werengowska-Ciecwierz, Karolina
[J]. ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY, 2013, 19 (2-4): : 269 - 272

← 1 2 3 4 5 →