Commentary: Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity

被引:0
|
作者
Freischmidt, Axel [1 ,2 ]
Brenner, David [1 ,3 ]
Ludolph, Albert C. [1 ,2 ]
Andersen, Peter M. [4 ]
Weishaupt, Jochen H. [1 ,3 ]
机构
[1] Ulm Univ, Dept Neurol, Ulm, Germany
[2] German Ctr Neurodegenerat Dis DZNE Ulm, Ulm, Germany
[3] Heidelberg Univ, Univ Med Mannheim, Neurol Dept, Div Neurodegenerat Dis, Mannheim, Germany
[4] Umea Univ, Dept Clin Sci, Neurosci, Umea, Sweden
关键词
amyotrophic lateral sclerosis; ALS; frontotemporal dementia; FTD; TBK1; neuroinflammation; genetic counseling; genetic variants; AMYOTROPHIC-LATERAL-SCLEROSIS; TBK1;
D O I
10.3389/fnins.2020.551006
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
引用
收藏
页数:2
相关论文
共 50 条
  • [41] mCSM-PPI2: predicting the effects of mutations on protein-protein interactions
    Rodrigues, Carlos H. M.
    Myung, Yoochan
    Pires, Douglas E. V.
    Ascher, David B.
    NUCLEIC ACIDS RESEARCH, 2019, 47 (W1) : W338 - W344
  • [42] The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1
    Li, Shun
    Lu, Long-Feng
    Wang, Zhao-Xi
    Lu, Xiao-Bing
    Chen, Dan-Dan
    Nie, Pin
    Zhang, Yong-An
    JOURNAL OF VIROLOGY, 2016, 90 (23) : 10728 - 10737
  • [43] Exploring additivity effects of double mutations on the binding affinity of protein-protein complexes
    Jemimah, Sherlyn
    Gromiha, M. Michael
    PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2018, 86 (05) : 536 - 547
  • [44] Intracellular localization and binding partners of death associated protein kinase-related apoptosis-inducing protein kinase 1
    Oue, Yuna
    Murakami, Sara
    Isshiki, Kinuka
    Tsuji, Akihiko
    Yuasa, Keizo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 496 (04) : 1222 - 1228
  • [45] Deep geometric representations for modeling effects of mutations on protein-protein binding affinity
    Liu, Xianggen
    Luo, Yunan
    Li, Pengyong
    Song, Sen
    Peng, Jian
    PLOS COMPUTATIONAL BIOLOGY, 2021, 17 (08)
  • [46] Effects of SARS-CoV-2 mutations on protein structures and intraviral protein-protein interactions
    Wu, Siqi
    Tian, Chang
    Liu, Panpan
    Guo, Dongjie
    Zheng, Wei
    Huang, Xiaoqiang
    Zhang, Yang
    Liu, Lijun
    JOURNAL OF MEDICAL VIROLOGY, 2021, 93 (04) : 2132 - 2140
  • [47] A CA2+-DEPENDENT PROTEIN-KINASE ACTIVITY ASSOCIATED WITH SEROTONIN BINDING-PROTEIN
    ADLERSBERG, M
    LIU, KP
    HSIUNG, SC
    EHRLICH, Y
    TAMIR, H
    JOURNAL OF NEUROCHEMISTRY, 1987, 49 (04) : 1105 - 1115
  • [48] Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis
    Smitha Pillai
    Jonathan Nguyen
    Joseph Johnson
    Eric Haura
    Domenico Coppola
    Srikumar Chellappan
    Nature Communications, 6
  • [49] Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis
    Pillai, Smitha
    Nguyen, Jonathan
    Johnson, Joseph
    Haura, Eric
    Coppola, Domenico
    Chellappan, Srikumar
    NATURE COMMUNICATIONS, 2015, 6
  • [50] Analysis of protein-protein interactions and the effects of amino acid mutations on their energetics. The importance of water molecules in the binding epitope
    Covell, DG
    Wallqvist, A
    JOURNAL OF MOLECULAR BIOLOGY, 1997, 269 (02) : 281 - 297