Pannexin-1 channels in epilepsy

被引:35
|
作者
Aquilino, Mark S. [1 ,3 ]
Whyte-Fagundes, Paige [2 ]
Zoidl, Georg [2 ,3 ]
Carlen, Peter L. [1 ,3 ]
机构
[1] Univ Toronto, IBBME, Rosebrugh Bldg,Room 407,164 Coll S4, Toronto, ON M5S 3G9, Canada
[2] York Univ, 4700 Keele St, Toronto, ON M3J 1P3, Canada
[3] Univ Hlth Network, Krembil Res Inst, 135 Nassau St, Toronto, ON M5T 1M8, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
Pannexin; Epilepsy; Seizure; Potassium; Glutamate; ATP; ATP RELEASE; RECEPTOR AGONISTS; NMDA RECEPTOR; P2Y RECEPTORS; EXPRESSION; ADENOSINE; GLUTAMATE; HEMICHANNELS; ACTIVATION; INHIBITION;
D O I
10.1016/j.neulet.2017.09.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Pannexin-1 (Panx1) expression is raised in several animal seizure models and in resected human epileptic brain tissue, suggesting relevance to epilepsy. Multiple factors that are characteristic of seizures are thought to regulate Panx1 channel opening, including elevated levels of extracellular K. Panx1, when open, 1) releases ATP, glutamate, and other metabolites into the extracellular medium, and 2) may depolarize the membrane due to a channel reversal potential around 0 mV. Resultant ATP release from stimulated Panx1 can activate purinergic receptors, including P2X7 receptors. Glutamate and other signaling molecules released by Panx1 opening may have both excitatory and inhibitory actions on seizure generation. This review examines the critical and complex roles of Panx1 channels in epilepsy, which could provide a basis for future therapeutics.
引用
收藏
页码:71 / 75
页数:5
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