Mice heterozygous for knockout of the insulin receptor are glucocompetent but are hypertensive and have impaired insulin stimulated vascular nitric oxide (NO) production

被引:0
|
作者
Wheatcroft, S [1 ]
Li, JM [1 ]
Crossey, P [1 ]
Noronha, B [1 ]
Shah, A [1 ]
Kearney, M [1 ]
机构
[1] Kings Coll London, Guys Kings & St Thomas Sch Med, Dept Cardiol, London WC2R 2LS, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
146
引用
收藏
页码:A43 / A43
页数:1
相关论文
共 50 条
  • [31] Defects of vascular nitric oxide bioavailability in subjects with impaired glucose tolerance: A potential link to insulin resistance
    Shimabukuro, Michio
    Higa, Namio
    Tagawa, Tatsuya
    Yamakawa, Ken
    Sata, Masataka
    Ueda, Shinichiro
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2013, 167 (01) : 298 - 300
  • [32] Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
    Zeng, GY
    Nystrom, FH
    Ravichandran, LV
    Cong, LN
    Kirby, M
    Mostowski, H
    Quon, MJ
    CIRCULATION, 2000, 101 (13) : 1539 - 1545
  • [33] Nitric oxide (NO) - Production and regulation of insulin secretion in islets of freely fed and fasted mice
    Eckersten, Dag
    Henningsson, Ragnar
    REGULATORY PEPTIDES, 2012, 174 (1-3) : 32 - 37
  • [34] Normal increases in insulin-stimulated glucose uptake after ex vivo contraction in neuronal nitric oxide synthase mu (nNOSμ) knockout mice
    Xinmei Zhang
    Xuzhu Lin
    Glenn K. McConell
    Pflügers Archiv - European Journal of Physiology, 2019, 471 : 961 - 969
  • [35] Normal increases in insulin-stimulated glucose uptake after ex vivo contraction in neuronal nitric oxide synthase mu (nNOS) knockout mice
    Zhang, Xinmei
    Lin, Xuzhu
    McConell, Glenn K.
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2019, 471 (07): : 961 - 969
  • [36] siRNA-mediated silencing of caveolin-1 inhibits insulin transport but enhances insulin-stimulated nitric oxide production
    Wang, Hong
    Wang, Aileen X.
    Barrett, Eugene J.
    DIABETES, 2008, 57 : A383 - A383
  • [37] Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine
    Doliba, NM
    Qin, W
    Vatamaniuk, MZ
    Li, CH
    Zelent, D
    Najafi, H
    Buettger, CW
    Collins, HW
    Carr, RD
    Magnuson, MA
    Matschinsky, FA
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2004, 286 (05): : E834 - E843
  • [38] Chromogranin A Knockout Mice Have Spontaneous Reversal of Hypertensive and Insulin Resistant Phenotypes as They Age (>1yr)
    Liu, Matthew
    Tang, Kechun
    Mahata, Sushil
    FASEB JOURNAL, 2021, 35
  • [39] Vasoreactivity of isolated aortic rings from dyslipidemic and insulin resistant inducible nitric oxide synthase knockout mice
    Pathak, Priya
    Kanshana, Jitendra S.
    Kanuri, BabuNageswar
    Rebello, Sanjay C.
    Aggarwal, Hobby
    Jagavelu, Kumaravelu
    Dikshit, Madhu
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 855 : 90 - 97
  • [40] Insulin like growth factor 1 increases vascular smooth muscle nitric oxide production
    Muniyappa, R
    Walsh, MF
    Rangi, JS
    Zayas, RM
    Standley, PR
    Ram, JL
    Sowers, JR
    LIFE SCIENCES, 1997, 61 (09) : 925 - 931