Mice heterozygous for knockout of the insulin receptor are glucocompetent but are hypertensive and have impaired insulin stimulated vascular nitric oxide (NO) production

被引：0
|
作者：
Wheatcroft, S [1 ]
Li, JM [1 ]
Crossey, P [1 ]
Noronha, B [1 ]
Shah, A [1 ]
Kearney, M [1 ]
机构：
[1] Kings Coll London, Guys Kings & St Thomas Sch Med, Dept Cardiol, London WC2R 2LS, England
来源：
HEART | 2004年 / 90卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
146
引用
收藏
页码：A43 / A43
页数：1
相关论文
共 50 条
  • [1] Heterozygous insulin receptor knockout mice are glucocompetent but have hypertension and impaired insulin stimulated nitric oxide release
    Wheatcroft, S
    Crossey, P
    Shah, A
    Norhona, B
    Kearney, M
    ATHEROSCLEROSIS, 2003, 170 (01) : S12 - S12
  • [2] Mice heterozygous for knockout of the insulin receptor are glucocompetent but have hypertension and resistance to insulin stimulated endothelial nitric oxide release
    Wheatcroft, SB
    Crossey, PA
    Noronha, BT
    Li, JM
    Shah, AM
    Kearney, MT
    CIRCULATION, 2003, 108 (17) : 135 - 135
  • [3] Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor
    Wheatcroft, SB
    Shah, AM
    Li, JM
    Duncan, E
    Noronha, BT
    Crossey, PA
    Kearney, MT
    DIABETES, 2004, 53 (10) : 2645 - 2652
  • [4] GLOBAL HETEROZYGOUS KNOCKOUT OF THE INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR IN MICE RESULTS IN ENHANCED METABOLIC AND VASCULAR INSULIN SENSITIVITY AND INCREASED ENDOTHELIAL NITRIC OXIDE PRODUCTION
    Abbas, A.
    Imrie, H.
    Viswambharan, H.
    Rajwani, A.
    Cubbon, R. M.
    Kahn, M. B.
    Wheatcroft, S. B.
    Grant, P. J.
    Kearney, M. T.
    HEART, 2009, 95 (22)
  • [5] Global Heterozygous Knockout of the Insulin-Like Growth Factor 1 Receptor in Mice Results in Enhanced Metabolic and Vascular Insulin Sensitivity and Increased Endothelial Nitric Oxide Production
    Abbas, Afroze
    Imrie, Helen
    Viswambharan, Hema
    Rajwani, Adil
    Cubbon, Richard M.
    Kahn, Matthew B.
    Wheatcroft, Stephen B.
    Grant, Peter J.
    Kearney, Mark T.
    DIABETES, 2009, 58 : A498 - A498
  • [6] Heterozygous Knockout of the Insulin-like Growth Factor 1 Receptor in Mice Leads to Enhanced Insulin Sensitivity and Increased Endothelial Nitric Oxide Production
    Abbas, Afroze
    Imrie, Helen
    Rajwani, Adil
    Viswambharan, Hema
    Cubbon, Richard M.
    Kahn, Matthew B.
    Wheatcroft, Stephen B.
    Grant, Peter J.
    Kearney, Mark T.
    CIRCULATION, 2008, 118 (18) : S465 - S465
  • [7] Insulin mediated nitric oxide production is impaired in insulin resistance
    Steinberg, HO
    Cressman, E
    Wu, YG
    Hook, G
    Cronin, J
    Johnson, A
    Baron, AD
    DIABETES, 1997, 46 : 92 - 92
  • [8] Nitric oxide-mediated apoptosis in astrocytes from insulin receptor knockout mice
    Makar, TK
    Accili, D
    Giovanni, G
    Milstien, S
    FASEB JOURNAL, 1997, 11 (09): : A1436 - A1436
  • [9] Mice with targeted knockout of insulin receptor from the proximal tubule have impaired glucose tolerance
    Tiwari, Swasti
    Gill, Pritmohinder S.
    Neilson, Eric G.
    Ecelbarger, Carolyn M.
    FASEB JOURNAL, 2008, 22
  • [10] Accelerated atherosclerosis in insulin receptor/insulin receptor substrate-1 double heterozygous apoe knockout mice
    Galkina, Elena
    Bruce, Anthony
    Pei, Hong
    Keller, Susanna R.
    Sarembock, Ian J.
    Sanders, John M.
    Kulkarni, Rohit N.
    Nadler, Jerry
    Ley, Klaus
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (06) : E116 - E116
12345