Antimalarial activity and cytotoxicity of zerumbone derivatives

被引：14

作者：

Sriphana, Uraiwan ^{[1
,2
]}

Pitchuanchom, Siripit ^{[1
,2
]}

Kongsaeree, Palangpon ^{[3
]}

Yenjai, Chavi ^{[1
,2
]}

机构：

[1] Khon Kaen Univ, Fac Sci, Dept Chem, Nat Prod Res Unit, Khon Kaen 40002, Thailand

[2] Khon Kaen Univ, Fac Sci, Ctr Excellence Innovat Chem, Khon Kaen 40002, Thailand

[3] Mahidol Univ, Fac Sci, Dept Chem, Bangkok 10400, Thailand

来源：

SCIENCEASIA | 2013年 / 39卷 / 01期

关键词：

Zingiber zerumbet; sesquiterpene; cyanozerumbone; Plasmodium falciparum; ZINGIBER-ZERUMBET; SESQUITERPENE; CHEMISTRY; CELLS;

D O I：

10.2306/scienceasia1513-1874.2013.39.095

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zerumbone, a sesquiterpene isolated from the rhizome of Zingiber zerumbet, shows strong antimalarial and cytotoxic activities. A series of zerumbone derivatives were synthesized and evaluated for in vitro antimalarial activity against Plasmodium falciparum and cytotoxicity against human cancer cell lines (NCI-H187, KB and BC) as well as normal cells (Vero cells). Three of the compounds showed potent antimalarial activity with IC50 values of 32.8, 13.7, and 9.8 mu M. They were less toxic against Vero cells.

引用

页码：95 / 99

页数：5

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