Anorexia Nervosa (AN) is characterized by serious malnutrition and metabolic derangement. Trace metal levels and other biochemical parameters were measured in 13 AN patients. Average serum copper concentration was 82.8+/-26 mu g/dl. Copper levels were below the lower limit of normal range in 46% of patients. Copper deficiency might be involved in reduced intake of food, via an impairment in smell and taste.