IMpassion130: Final OS analysis from the pivotal phase III study of atezolizumab plus nab-paclitaxel vs placebo plus nab-paclitaxel in previously untreated locally advanced or metastatic triple-negative breast cancer

被引:52
|
作者
Emens, L. A. [1 ]
Adams, S. [2 ]
Barrios, C. H. [3 ]
Dieras, V. C. [4 ]
Iwata, H. [5 ]
Loi, S. [6 ]
Rugo, H. S. [7 ]
Schneeweiss, A. [8 ]
Winer, E. P. [9 ]
Patel, S. [10 ]
Henschel, V. [11 ]
Swat, A. [12 ]
Kaul, M. [13 ]
Molinero, L. [14 ]
Chui, S. Y. [15 ]
Schmid, P. [16 ]
机构
[1] UPMC Hillman Canc Ctr, Dept Med Hematol Oncol, Pittsburgh, PA USA
[2] NYU, Langone Med Ctr, Sch Med, New York, NY USA
[3] Pontificia Univ Catolica Rio Grande do Sul, Hosp Sao Lucas, Invest Ctr, Porto Alegre, RS, Brazil
[4] Ctr Eugene Marquis, Med Oncol, Rennes, France
[5] Aichi Canc Ctr Hosp, Breast Oncol, Nagoya, Aichi, Japan
[6] Peter MacCallum Canc Ctr, Div Res, Translat Breast Canc Genom Lab, Melbourne, Vic, Australia
[7] UCSF, Helen Diller Family Comprehens Canc Ctr, Breast Dept, San Francisco, CA USA
[8] Univ Hosp Heidelberg, German Canc Res Ctr, Heidelberg, Germany
[9] Dana Farber Canc Inst, Med, Boston, MA 02115 USA
[10] Genentech Inc, Med Oncol, San Francisco, CA USA
[11] Genentech Inc, Biostat, San Francisco, CA USA
[12] F Hoffmann La Roche, Clin Sci, Basel, Switzerland
[13] F Hoffmann La Roche, Canc Immunotherapy Clin Safety, Basel, Switzerland
[14] Genentech Inc, Oncol Biomarker Dev, San Francisco, CA 94080 USA
[15] Genentech Inc, Prod Dev Oncol, San Francisco, CA 94080 USA
[16] Queen Mary Univ London, Barts Canc Inst, London, England
关键词
D O I
10.1016/j.annonc.2020.08.2244
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LBA16
引用
收藏
页码:S1148 / S1148
页数:1
相关论文
共 50 条
  • [21] IMpassion130: Phase III trial comparing 1L atezolizumab with nab-paclitaxel versus placebo with nab-paclitaxel in treatment-naive patients with mTNBC
    Emens, L.
    Adams, S.
    Loi, S.
    Schneeweiss, A.
    Rugo, H.
    Winer, E.
    Barrios, C.
    Dieras, V.
    de la Haba-Rodriguez, J.
    Gianni, L.
    Kusuma, N.
    Chui, S. Y.
    Schmid, P.
    ANNALS OF ONCOLOGY, 2016, 27
  • [22] Atezolizumab plus nab-paclitaxel as first line therapy in Japanese patients with TNBC: A subgroup analysis of IMpassion130
    Inoue, Kenichi
    Shimomura, Akihiko
    Kaneko, Koji
    Ito, Yoshinori
    Tsugawa, Koichiro
    Yamauchi, Teruo
    Tsurutani, Junji
    Niikura, Naoki
    Sawaki, Masataka
    Doihara, Hiroyoshi
    Miyoshi, Yasuo
    Hasegawa, Ayumi
    Nakagawa, Shintaro
    Kuratomi, Hiroyasu
    Iwata, Hiroji
    ANNALS OF ONCOLOGY, 2019, 30
  • [23] Atezolizumab (in Combination with Nab-Paclitaxel): A Review in Advanced Triple-Negative Breast Cancer
    Kang, Connie
    Syed, Yahiya Y.
    DRUGS, 2020, 80 (06) : 601 - 607
  • [24] Atezolizumab (in Combination with Nab-Paclitaxel): A Review in Advanced Triple-Negative Breast Cancer
    Connie Kang
    Yahiya Y. Syed
    Drugs, 2020, 80 : 601 - 607
  • [25] Mechanisms of action and acquired resistance to atezolizumab plus nab-paclitaxel in metastatic triple-negative breast cancer (mTNBC).
    Molinero, Luciana
    Emens, Leisha A.
    Goldstein, Leonard D.
    Abbas, Alexander R.
    Koeppen, Hartmut
    Rugo, Hope S.
    Adams, Sylvia
    Chui, Stephen Y.
    Schmid, Peter
    Loi, Sherene
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (16)
  • [26] IMpassion130: Efficacy in immune biomarker subgroups from the global, randomized, double-blind, placebo-controlled, phase III study of atezolizumab plus nab-paclitaxel in patients with treatment-naive, locally advanced or metastatic triple-negative breast cancer
    Emens, L. A.
    Loi, S.
    Rugo, H. S.
    Schneeweiss, A.
    Dieras, V.
    Iwata, H.
    Barrios, C. H.
    Nechaeva, M.
    Molinero, L.
    Duc, A. Nguyen
    Funke, R.
    Chui, S. Y.
    Husain, A.
    Winer, E. P.
    Adams, S.
    Schmid, P.
    CANCER RESEARCH, 2019, 79 (04)
  • [27] Tumour mutational burden and clinical outcomes with first-line atezolizumab and nab-paclitaxel in triple-negative breast cancer: Exploratory analysis of the phase III IMpassion130 trial
    Emens, L. A.
    Molinero, L.
    Adams, S.
    Rugo, H. S.
    Schneeweiss, A.
    Dieras, V.
    Iwata, H.
    Barrios, C. H.
    Nechaeva, M.
    Winer, E. P.
    Chang, C. W.
    Chui, S. Y.
    Schmid, P.
    Loi, S.
    ANNALS OF ONCOLOGY, 2020, 31 : S360 - S361
  • [28] Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial
    Schmid, Peter
    Rugo, Hope S.
    Adams, Sylvia
    Schneeweiss, Andreas
    Barrios, Carlos H.
    Iwata, Hiroji
    Dieras, Veronique
    Henschel, Volkmar
    Molinero, Luciana
    Chui, Stephen Y.
    Maiya, Vidya
    Husain, Amreen
    Winer, Eric P.
    Loi, Sherene
    Emens, Leisha A.
    LANCET ONCOLOGY, 2020, 21 (01): : 44 - 59
  • [29] Genomic profiling and clinical outcomes with first-line atezolizumab and nab-paclitaxel in triple-negative breast cancer: An exploratory analysis from the phase 3 IMpassion130 trial
    Emens, Leisha
    Molinero, Luciana
    Adams, Sylvia
    Rugo, Hope S.
    Schneeweiss, Andreas
    Dieras, Veronique
    Iwata, Hiroji
    Barrios, Carlos
    Winer, Eric P.
    Chang, Ching-Wei
    Chui, Stephen Y.
    Schmid, Peter
    Loi, Sherene
    CANCER RESEARCH, 2021, 81 (04)
  • [30] Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial
    Jiang, Zefei
    Ouyang, Quchang
    Sun, Tao
    Zhang, Qingyuan
    Teng, Yuee
    Cui, Jiuwei
    Wang, Haibo
    Yin, Yongmei
    Wang, Xiaojia
    Zhou, Xin
    Wang, Yongsheng
    Sun, Gang
    Wang, Jingfen
    Zhang, Lili
    Yang, Jin
    Qian, Jun
    Yan, Min
    Liu, Xinlan
    Yi, Tienan
    Cheng, Ying
    Li, Man
    Zang, Aimin
    Wang, Shusen
    Wang, Chuan
    Wu, Xinhong
    Cheng, Jing
    Li, Hui
    Lin, Ying
    Geng, Cuizhi
    Gu, Kangsheng
    Xie, Chunwei
    Xiong, Huihua
    Wu, Xiaohong
    Yang, Junlan
    Li, Qingshan
    Chen, Yiding
    Li, Fanfan
    Zhang, Anqin
    Zhang, Yongqiang
    Wu, Yudong
    Nie, Jianyun
    Liu, Qiang
    Wang, Kun
    Mo, Xueli
    Chen, Lilin
    Pan, Yueyin
    Fu, Peifen
    Zhang, Helong
    Pang, Danmei
    Sheng, Yuan
    NATURE MEDICINE, 2024, 30 (02) : 249 - 256