A novel pH "off-on" fluorescent probe for lysosome imaging

被引：33

作者：

Chen, Laizhong ^{[1
]}

Li, Jing ^{[1
]}

Liu, Zhenzhen ^{[1
]}

Ma, Zhao ^{[1
]}

Zhang, Wei ^{[1
]}

Du, Lupei ^{[1
]}

Xu, Wenfang ^{[1
]}

Fang, Hao ^{[1
]}

Li, Minyong ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Key Lab Chem Biol, MOE,Sch Pharm, Jinan 250012, Shandong, Peoples R China

来源：

RSC ADVANCES | 2013年 / 3卷 / 32期

关键词：

D O I：

10.1039/c3ra41898g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present paper, a new pH sensitive fluorescent probe based on a 4-acylated naphthalimide fluorophore was well designed and synthesized. It has a high specificity for lysosomes over other cell organelles. The intrinsic high signal to noise ratio in cell imaging, broad Stokes shift and practical fluorescence quantum yield of this probe will ensure its prominent position in the intracellular lysosome targeting and imaging toolbox.

引用

页码：13412 / 13416

页数：5

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