Portable spectroscopic system for in vivo skin neoplasms diagnostics by Raman and autofluorescence analysis

被引：47
|
作者：
Khristoforova, Yulia A. [1 ]
Bratchenko, Ivan A. [1 ]
Myakinin, Oleg O. [1 ]
Artemyev, Dmitry N. [1 ]
Moryatov, Alexander A. [2 ,3 ]
Orlov, Andrey E. [3 ]
Kozlov, Sergey V. [2 ,3 ]
Zakharov, Valery P. [1 ]
机构：
[1] Samara Natl Res Univ, Dept Laser & Biotech Syst, 34 Moskovskoe Shosse, Samara 443086, Russia
[2] Samara State Med Univ, Dept Oncol, Samara, Russia
[3] Samara Reg Clin Oncol Dispensary, Dept Visual Localizat Tumors, Samara, Russia
来源：
JOURNAL OF BIOPHOTONICS | 2019年 / 12卷 / 04期
关键词：
autofluorescence; malignancy; melanoma; optical biopsy; partial least square analysis; portable spectroscopic equipment; Raman spectroscopy; skin neoplasms; NAKED-EYE EXAMINATION; BASAL-CELL CARCINOMA; DISCRIMINATION; MELANOMA; CANCER; DERMOSCOPY; ACCURACY; LESIONS;
D O I：
10.1002/jbio.201800400
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The present paper studies the applicability of a portable cost-effective spectroscopic system for the optical screening of skin tumors. in vivo studies of Raman scattering and autofluorescence (AF) of skin tumors with the 785 nm excitation laser in the near-infrared region included malignant melanoma, basal cell carcinoma and various types of benign neoplasms. The efficiency of the portable system was evaluated by comparison with a highly sensitive spectroscopic system and with the diagnosis accuracy of a human oncologist. Partial least square analysis of Raman and AF spectra was performed; specificity and sensitivity of various skin oncological pathologies detection varied from 78.9% to 100%. Hundred percent accuracy of benign and malignant skin tumors differentiation is possible only with a combined analysis of Raman and AF signals.
引用
收藏
页数：11
相关论文
共 50 条
  • [31] Spectroscopic analysis using a hybrid LIBS-Raman system
    Giakoumaki, A.
    Osticioli, I.
    Anglos, D.
    HERITAGE, WEATHERING AND CONSERVATION, VOLS 1 AND 2, 2006, : 633 - 637
  • [32] Design and Development of Portable Galvanic Skin Response Acquisition and Analysis System
    Das, Priyanka
    Das, Abhik
    Tibarewala, D. N.
    Khasnobish, Anwesha
    2016 INTERNATIONAL CONFERENCE ON INTELLIGENT CONTROL POWER AND INSTRUMENTATION (ICICPI), 2016, : 127 - 131
  • [33] Human skin phototype and apparent age classification based on machine learning methods of autofluorescence and diffuse reflectance spectroscopic data acquired in vivo
    Zghal, Ahmed
    Fauvel, Clement
    Kupriyanov, Valentin
    Elsen, Thomas
    Khairallah, Gregoire
    Blondel, Walter
    Amouroux, Marine
    ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC AND SURGICAL GUIDANCE SYSTEMS XXI, 2023, 12368
  • [34] Human skin phototype and apparent age classification based on machine learning methods of autofluorescence and diffuse reflectance spectroscopic data acquired in vivo
    Zghal, Ahmed
    Fauvel, Clement
    Kupriyanov, Valentin
    Elsen, Thomas
    Khairallah, Gregoire
    Blondel, Walter
    Amouroux, Marine
    QUANTUM TECHNOLOGY: DRIVING COMMERCIALISATION OF AN ENABLING SCIENCE III, 2022, 12335
  • [35] Tumor identification via in vivo portable Raman detection of sialic acid with a dual gold nanoprobe system
    Wang, Yuru
    Yang, Yuanjiao
    Guo, Jingxing
    Ju, Huangxian
    Chen, Yunlong
    CHEMICAL SCIENCE, 2023, 14 (04) : 923 - 927
  • [36] Analysis of Human and Porcine Skin in vivo/ex vivo for Penetration of Selected Oils by Confocal Raman Microscopy
    Choe, Chunsik
    Lademann, Juergen
    Darvin, Maxim E.
    SKIN PHARMACOLOGY AND PHYSIOLOGY, 2015, 28 (06) : 318 - 330
  • [37] Confocal Raman spectroscopic microscopy tracks the penetration of two permeation enhancers in intact human skin ex vivo
    Zhang, Qihong
    Pyatski, Yelena
    Flach, Carol
    Mendelsohn, Richard
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [38] Fused Raman spectroscopic analysis of blood and saliva delivers high accuracy for head and neck cancer diagnostics
    Hanna J. Koster
    Antonio Guillen-Perez
    Juan Sebastian Gomez-Diaz
    Maria Navas-Moreno
    Andrew C. Birkeland
    Randy P. Carney
    Scientific Reports, 12
  • [39] Fused Raman spectroscopic analysis of blood and saliva delivers high accuracy for head and neck cancer diagnostics
    Koster, Hanna J.
    Guillen-Perez, Antonio
    Gomez-Diaz, Juan Sebastian
    Navas-Moreno, Maria
    Birkeland, Andrew C.
    Carney, Randy P.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [40] Microwave Reflectometry Sensing System for Low-Cost in-vivo Skin Cancer Diagnostics
    Schiavoni, Raissa
    Maietta, Gennaro
    Filieri, Elisabetta
    Masciullo, Antonio
    Cataldo, Andrea
    IEEE ACCESS, 2023, 11 : 13918 - 13928
12345